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NNMTi

NNMTi is a nicotinamide N-methyltransferase (NNMT) inhibitor that promotes myoblast differentiation.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
NNMTi(CAS 42464-96-0)

CAT No: R1939

CAS No:42464-96-0

Synonyms/Alias:NNMTi;42464-96-0;5-AMINO-1-METHYLQUINOLIN-1-IUM IODIDE;5-amino-1-methylquinolinium iodide;5-Amino-1-methylquinolin-1-iumiodide;MFCD22125886;NNMTi?;5-Amino-1-mq iodide;Compound 1k, NNMT inhibitor;CHEMBL4088008;SCHEMBL21814312;AKOS015953375;1-methylquinolin-1-ium-5-amine;iodide;5-Amino-1-methyl-1-quinolinium Iodide;BS-49094;DA-56226;SY275924;HY-131042;CS-0121050;E71261;

Chemical Name:1-methylquinolin-1-ium-5-amine;iodide

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M.F/Formula
C10H11IN2
M.W/Mr.
286.11
Appearance
Solid powder
Biological Activity
Nicotinamide N-methyltransferase (NNMT) inhibitor (IC50 = 1.2 μM). Promotes myoblast differentiation in C2C12 cells. Activates senescent muscle stem cells (muSCs) and improves regenerative capacity of aged skeletal muscle. Enhances proliferation, fusion and regenerative capacity of muSCs in aged mice.
Long-term Storage Conditions
Soluble in DMSO
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
InChI
InChI=1S/C10H10N2.HI/c1-12-7-3-4-8-9(11)5-2-6-10(8)12;/h2-7,11H,1H3;1H
InChI Key
JPEZFBFIRRAFNR-UHFFFAOYSA-N
Canonical SMILES
C[N+]1=CC=CC2=C(C=CC=C21)N.[I-]
References
1. Neelakantan et al (2019) Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. Biochem. Pharmacol. 163 481 PMID: 30753815
2.Neelakantan et al (2017) Structure-activity relationship for small molecule inhibitors of nicotinamide N-methyltransferase. J.Med.Chem. 60 5015 PMID: 28548833

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