Nonapeptide-1 acetate salt, a peptide hormone, is a potent α-Melanocyte-stimulating hormone (α-MSH) antagonist, with an IC50 of 11 nM. Reduces synthesis of melanin and helps decrease skin pigmentation to a substantial degree.
Nonapeptide-1 acetate salt is a synthetic peptide composed of nine amino acid residues, formulated in its acetate salt form to enhance stability and solubility for laboratory use. As a member of the nonapeptide family, it is recognized for its ability to interact with specific cellular targets, making it a valuable research tool in the study of peptide signaling, receptor-ligand interactions, and cellular regulation. Its defined sequence and physicochemical properties support a wide range of experimental applications in peptide biochemistry, molecular biology, and cell-based assays, enabling precise exploration of peptide-driven mechanisms in various biological contexts.
Peptide signaling research: In the field of cell signaling, Nonapeptide-1 analogs are frequently employed to investigate the modulation of intracellular pathways mediated by peptide ligands. Researchers utilize this compound to probe the specificity, affinity, and downstream effects of peptide-receptor interactions, particularly in studies focused on G protein-coupled receptors (GPCRs) and other membrane-associated targets. By serving as a model ligand, it facilitates the dissection of signal transduction processes and aids in mapping the functional consequences of peptide-mediated cellular communication.
Receptor binding studies: The acetate salt of this nonapeptide is often used in quantitative binding assays to characterize the pharmacological profile of peptide receptors. Its defined structure allows for the assessment of receptor selectivity, competitive binding, and kinetic parameters in vitro. Such studies are essential for elucidating the molecular determinants of ligand recognition and for screening novel receptor modulators in drug discovery pipelines. The compound's stability and solubility make it particularly well-suited for high-throughput screening and detailed mechanistic investigations.
Peptide synthesis and modification: Nonapeptide-1 acetate salt serves as a reference standard and positive control in solid-phase peptide synthesis and structural modification protocols. Synthetic chemists and peptide engineers employ it to optimize coupling strategies, confirm synthetic fidelity, and validate purification workflows. Its use as a benchmark compound enables accurate calibration of analytical instrumentation such as HPLC and mass spectrometry, ensuring reproducibility and quality control in peptide production environments.
Cellular assay development: In cellular and molecular biology labs, this nonapeptide is incorporated into a variety of functional assays designed to monitor cellular responses to peptide stimuli. Applications include the evaluation of intracellular signaling cascades, gene expression changes, and phenotypic alterations upon peptide exposure. The compound's predictable activity profile supports the design of robust, reproducible assays for screening peptide analogs, studying desensitization phenomena, and modeling physiological peptide functions in vitro.
Structure-activity relationship (SAR) analysis: Nonapeptide-1 derivatives are pivotal in SAR studies aimed at correlating peptide sequence variations with biological activity. By systematically substituting amino acid residues or modifying terminal groups, researchers can delineate the structural features critical for receptor engagement and functional efficacy. The acetate salt form is preferred in these studies for its enhanced solubility and compatibility with a range of analytical and biological assay systems, facilitating detailed exploration of peptide structure-function relationships.
2. An Open-label, Single-center, Safety and Efficacy Study of Eyelash Polygrowth Factor Serum
3. Cell-based adhesion assays for isolation of snake venom’s integrin antagonists
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