Nonapeptide-1 is a synthetic peptide composed of nine amino acids, designed for use in cosmetic formulations targeting skin tone uniformity and radiance. By modulating the appearance of pigmentation, Nonapeptide-1 offers formulators a tool to address uneven skin tone in a variety of product types, including serums and creams. Its compatibility with common cosmetic ingredients supports versatile application in global skincare product development.
CAT No: CPC1650
CAS No:158563-45-2
Synonyms/Alias:Nonapeptide-1;158563-45-2;H-Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2;White 05;Melanostatine 5;Nonapeptide-1 [INCI];(Met5,pro6,d-phe7,d-trp9,phe10)-alpha-msh (5-13);L-Valinamide, L-methionyl-L-prolyl-D-phenylalanyl-L-arginyl-D-tryptophyl-L-phenylalanyl-L-lysyl-L-prolyl-;UNII-64W45420K5;Met-pro-phe-arg-trp-phe-lys-pro-val;64W45420K5;Nonapeptide-1 (acetate);MFCD00672435;(S)-1-(L-methionyl)-N-((R)-1-(((S)-1-(((R)-1-(((S)-1-(((S)-6-amino-1-((S)-2-(((S)-1-amino-3-methyl-1-oxobutan-2-yl)carbamoyl)pyrrolidin-1-yl)-1-oxohexan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)pyrrolidine-2-carboxamide;Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2;(Met5,Pro6,D-Phe7,D-Trp9,Phe10)-a-MSH (5-13);KNFLNGRLKALWRF-LDXSYGEZSA-N;HY-P0097;AKOS030632860;AC-31945;DA-69171;DS-19607;FM108756;CS-0017927;C72990;Q27263795;(Met5,Pro6,D-Phe7,D-Trp9,Phe10)-?-MSH (5-13);Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2;Nonapeptide 1;(2S)-N-[(1R)-1-{[(1S)-1-{[(2S)-6-amino-1-[(2S)-2-{[(1S)-1-carbamoyl-2-methylpropyl]carbamoyl}pyrrolidin-1-yl]-1-oxohexan-2-yl]carbamoyl}-2-phenylethyl]carbamoyl}-2-(1H-indol-3-yl)ethyl]-2-[(2R)-2-{[(2S)-1-[(2S)-2-amino-4-(methylsulfanyl)butanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanamido]-5-carbamimidamidopentanamide;
Mechanism of Action (MOA)
Nonapeptide-1 is a biomimetic peptide that interacts with the melanocortin pathway in skin cells. By competitively binding to the melanocortin-1 receptor (MC1R) on melanocytes, it modulates the signaling cascade associated with melanin synthesis. This activity may help balance the expression of key enzymes involved in pigmentation processes. Nonapeptide-1 offers a targeted approach to influencing cellular communication pathways related to visible skin tone uniformity.
Nonapeptide-1 can be incorporated into a variety of cosmetic formulations to support targeted skincare routines.
- Suitable for use in facial serums and creams- Can be added to lotions designed for daily skincare- Compatible with gel-based formulations for lightweight applications- May be included in sheet masks and leave-on treatments- Appropriate for formulations intended for overall skin tone care- Recommended concentration and processing conditions should be followed
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