NoxA1ds

Name: NoxA1ds
Brand: Creative Peptides
SKU: R1050
Availability: MadeToOrder

Cell permeable, potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM), which exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. It inhibits NOX1-derived O2- production in HT-29 human colon cancer cells, and attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro.

Please kindly note that our products and services can only be used to support research purposes (Not for clinical use).

CAT No: R1050

CAS No: 1435893-78-9

Synonyms/Alias: NoxA1ds;1435893-78-9;AKOS027470303;PD079935;G15861;

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Specification Technical Data Publications Customer reviews and Q&A

M.F/Formula	C50H88N14O15
M.W/Mr.	1125.3
Sequence	One Letter Code:EPVDALGKAKV Three Letter Code:H-Glu-Pro-Val-Asp-Ala-Leu-Gly-Lys-Ala-Lys-Val-NH2
Labeling Target	NADPH oxidase 1 (NOX1)
Activity	Inhibitor

InChI	InChI=1S/C50H88N14O15/c1-25(2)22-33(44(73)55-24-36(65)58-31(14-9-11-19-51)45(74)56-28(7)42(71)59-32(15-10-12-20-52)46(75)62-39(26(3)4)41(54)70)60-43(72)29(8)57-47(76)34(23-38(68)69)61-49(78)40(27(5)6)63-48(77)35-16-13-21-64(35)50(79)30(53)17-18-37(66)67/h25-35,39-40H,9-24,51-53H2,1-8H3,(H2,54,70)(H,55,73)(H,56,74)(H,57,76)(H,58,65)(H,59,71)(H,60,72)(H,61,78)(H,62,75)(H,63,77)(H,66,67)(H,68,69)/t28-,29-,30-,31-,32-,33-,34-,35-,39-,40-/m0/s1
InChI Key	DHBOJLLJKHKZGT-XTGVMIFDSA-N
Isomeric SMILES	C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)N

1. Zeta-potential-changing nanoparticles conjugated with cell-penetrating peptides for enhanced transfection efficiency

2. Olfactory receptor based piezoelectric biosensors for detection of alcohols related to food safety applications

3. Constitutive and inflammation-dependent antimicrobial peptides produced by epithelium are differentially processed and inactivated by the commensal Finegoldia magna and the pathogen Streptococcus pyogenes

4. Sex differences in oxidative stress level and antioxidative enzymes expression and activity in obese pre-diabetic elderly rats treated with metformin or liraglutide

5. C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy

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