Ntfapi presents a peptide scaffold containing varied functional groups that drive diverse folding states and solubility patterns. Researchers analyze hydrogen-bonding tendencies and charge distribution. Its conformational adaptability aids interaction profiling. Applications span ligand design, structural exploration, and peptide optimization.
CAT No: R2536
CAS No:2374782-03-1
Synonyms/Alias:NTFAPI;NOTA-FAPI;2374782-03-1;NOTA-FAPI-04;RD4ZKJ67G3;FAPI-42;(S)-2,2'-(7-(2-(4-(3-((4-((2-(2-Cyano-4,4-difluoropyrrolidin-1-yl)-2-oxoethyl)carbamoyl)quinolin-6-yl)oxy)propyl)piperazin-1-yl)-2-oxoethyl)-1,4,7-triazonane-1,4-diyl)diacetic acid;1H-1,4,7-Triazonine-1,4(5H)-diacetic acid, 7-(2-(4-(3-((4-(((2-((2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl)-2-oxoethyl)amino)carbonyl)-6-quinolinyl)oxy)propyl)-1-piperazinyl)-2-oxoethyl)hexahydro-;1H-1,4,7-Triazonine-1,4(5H)-diacetic acid, 7-[2-[4-[3-[[4-[[[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]amino]carbonyl]-6-quinolinyl]oxy]propyl]-1-piperazinyl]-2-oxoethyl]hexahydro-;UNII-RD4ZKJ67G3;SCHEMBL21257092;XQARGGQZFNOLDH-SANMLTNESA-N;EX-A4616;AT43727;HY-136641;CS-0132761;2-[4-(carboxymethyl)-7-[2-[4-[3-[4-[[2-[(2S)-2-cyano-4,4-difluoropyrrolidin-1-yl]-2-oxoethyl]carbamoyl]quinolin-6-yl]oxypropyl]piperazin-1-yl]-2-oxoethyl]-1,4,7-triazonan-1-yl]acetic acid;
Ntfapi, also known as N-Trimethylammonium-Functionalized Polyisoprene, is a specialized carbohydrate compound renowned for its unique molecular architecture and versatile physicochemical properties. Distinguished by its cationic trimethylammonium groups, Ntfapi exhibits excellent solubility in aqueous systems and remarkable compatibility with a range of biological and synthetic matrices. Its amphiphilic nature allows for tailored interactions with both hydrophilic and hydrophobic substances, making it a valuable asset in various scientific and industrial research domains. The structural flexibility and chemical stability of Ntfapi further enhance its appeal for applications requiring robust performance under diverse conditions, positioning it as a promising material for innovative research and development endeavors.
Polymer Modification: In the field of advanced materials science, Ntfapi serves as an effective modifier for synthetic and natural polymers. By introducing its cationic functional groups into polymeric matrices, researchers can significantly alter surface charge, hydrophilicity, and interfacial properties. This modification enables the production of materials with enhanced adhesion, improved dispersion, and tailored compatibility with other functional additives. The ability to fine-tune these properties is particularly beneficial for developing smart coatings, responsive hydrogels, and high-performance composites, where precise control over physical and chemical interactions is critical.
Gene Delivery Systems: Ntfapi's cationic nature makes it an ideal candidate for constructing non-viral gene delivery vectors. Its trimethylammonium groups facilitate strong electrostatic interactions with negatively charged nucleic acids, promoting the formation of stable polyplexes. These complexes can protect genetic material from degradation and improve cellular uptake efficiency, which is essential for in vitro gene transfection studies. The amphiphilic character of Ntfapi further aids in traversing cellular membranes, thereby enhancing the delivery of genetic payloads into target cells for research into gene expression and regulation mechanisms.
Antimicrobial Coatings: The incorporation of Ntfapi into surface coatings imparts potent antimicrobial properties due to its quaternary ammonium structure. These cationic functionalities disrupt microbial cell membranes through electrostatic interactions, leading to reduced microbial adhesion and proliferation on treated surfaces. Such coatings are particularly valuable in laboratory and industrial settings where contamination control is paramount. The durability and efficacy of Ntfapi-based coatings contribute to maintaining sterile environments and extending the functional lifespan of equipment and materials.
Analytical Chemistry: Ntfapi is utilized in analytical chemistry as a functional additive for enhancing the performance of separation techniques such as capillary electrophoresis and liquid chromatography. Its unique charge characteristics enable improved resolution and selectivity when analyzing complex carbohydrate mixtures or biomolecules. By modulating the electroosmotic flow and interacting selectively with analytes, Ntfapi helps achieve more precise and reproducible separations. Researchers benefit from its compatibility with a wide range of solvents and detection systems, facilitating the development of sensitive and high-throughput analytical protocols.
Biomaterials Engineering: In the realm of biomaterials engineering, Ntfapi is employed to fabricate and functionalize scaffolds for tissue engineering and regenerative research. Its amphiphilic and cationic features support cell adhesion, proliferation, and differentiation by mimicking aspects of the natural extracellular matrix. Ntfapi-modified scaffolds can be engineered to present bioactive cues or deliver signaling molecules, thereby enhancing cellular responses and tissue integration in experimental models. The versatility of this carbohydrate compound enables the customization of biomaterial properties for a variety of research-driven applications, including 3D cell culture platforms and biocompatible implant prototypes.
Surface Functionalization: Beyond these core applications, Ntfapi finds utility in surface functionalization strategies for microfluidic devices, biosensors, and diagnostic platforms. Its ability to impart specific charge characteristics and hydrophilic surfaces supports the immobilization of biomolecules, reduction of nonspecific binding, and improvement of signal-to-noise ratios in analytical assays. The ease with which Ntfapi can be integrated into diverse substrate materials adds to its value as a multifunctional reagent in the design and optimization of next-generation research tools.
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