Oxytocin, Asp(5)- replaces a native residue at position five with aspartate, shifting local charge and hydrogen-bonding capacity within the cyclic ring. The substitution modulates backbone geometry and side-chain interactions important for receptor recognition. Researchers compare its solution structure and binding behavior to native oxytocin. Applications include cyclic-peptide engineering, SAR exploration, and motif-function mapping.
CAT No: R2374
CAS No:65907-78-0
Synonyms/Alias:5-Asp-oxytocin;65907-78-0;Oxytocin, aspartic acid(5)-;Oxytocin, asp(5)-;Oxytocin, 5-L-aspartic acid-;2-[(4R,7S,10S,16S,19R)-19-amino-4-[(2S)-2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]carbamoyl]pyrrolidine-1-carbonyl]-10-(3-amino-3-oxopropyl)-13-[(2S)-butan-2-yl]-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-7-yl]acetic acid;[Asp5]-Oxytocin;SCHEMBL15511486;G18218;
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