Pegcetacoplan combines a complement-targeting cyclic peptide with polyethylene glycol chains to modulate solubility and hydrodynamic radius. The PEGylated architecture decreases aggregation and can prolong circulation in model systems. Researchers examine its binding to complement components, conformational features, and complex formation. Applications include complement-pathway mechanism studies, ligand-protein interaction analysis, and bioconjugate-engineering work.
CAT No: R2736
CAS No:2019171-69-6
Synonyms/Alias:Pegcetacoplan; 2019171-69-6; TO3JYR3BOU; Syfovre; APL-2; APL 2; APL-2 peptide; APL2; O,O'-BIS((S2,S12-CYCLO(N-ACETYL-L-ISOLEUCYL-L-CYSTEINYL-L-VALYL-1-METHYL-L-TRYPTOPHYL-L-GLUTAMINYL-L-alpha-ASPARTYL-L-TRYPTOPHYLGLYCYL-L-ALANYL-L-HISTIDYL-L-ARGINYL-L-CYSTEINYL-L-THREONYL-2-(2-(2-AMINOETHOXY)ETHOXY)ACETYL-L-LYSINAMIDE))-N6.15-CARBONYL)POLYETHYLENE GLYCOL (N = 800-1100); POLY(OXY-1,2-ETHANEDIYL), alpha-HYDRO-omega-HYDROXY-, 15,15'-DIESTER WITH N-ACETYL-L-ISOLEUCYL-L-CYSTEINYL-L-VALYL-1-METHYL-L-TRYPTOPHYL-L-GLUTAMINYL-L-alpha-ASPARTYL-L-TRYPTOPHYLGLYCYL-L-ALANYL-L-HISTIDYL-L-ARGINYL-L-CYSTEINYL-L-THREONYL-2-(2-(2-AMINOETHOXY)ETHOXY)ACETYL-N6-CARBOXY-L-LYSINAMIDE CYCLIC (2->12)-(DISULFIDE); UNII-TO3JYR3BOU; pegcetacoplanum
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