Peptide5 offers a modular peptide sequence used to explore receptor-associated motifs and conformational plasticity. Residue diversity facilitates binding studies and folding assessments. Researchers evaluate its dynamic structural behavior across environments. Uses include structural biology, ligand optimization, and mechanistic analysis.
CAT No: R2341
CAS No:916977-43-0
Synonyms/Alias:Peptide5;916977-43-0;Peptide 5 trifluoroacetate salt;L-Threonine,L-valyl-L-a-aspartyl-L-cysteinyl-L-phenylalanyl-L-leucyl-L-seryl-L-arginyl-L-prolyl-L-threonyl-L-a-glutamyl-L-lysyl-;Peptide5?;CHEMBL4743934;HY-P2275;AKOS034831582;AS-88473;DA-66580;PD080225;CS-0121060;G79465;
Peptide5 is a synthetic peptide compound recognized for its role as a selective gap junction inhibitor, specifically targeting connexin43 (Cx43) hemichannels. Structurally engineered to mimic a segment of the extracellular loop of Cx43, Peptide5 is widely valued in scientific research for its ability to modulate intercellular communication without eliciting cytotoxic effects. Researchers appreciate its high specificity and reversible action, which allow for precise temporal and spatial control in experimental settings. The peptide's stability in various biological environments, coupled with its ease of synthesis and handling, makes it a preferred tool for exploring cellular signaling pathways and tissue response mechanisms.
Neuroscience research: Peptide5 has become an essential molecule for investigating the role of gap junctions in neurophysiological and neuropathological processes. By selectively inhibiting Cx43 hemichannels, it enables researchers to dissect the contribution of astrocytic and neuronal communication to neural network synchronization, neuroinflammation, and excitotoxicity. Its application in in vitro and ex vivo brain models has provided insights into how altered gap junctional coupling affects neuronal survival and glial function under stress or injury conditions, advancing the understanding of central nervous system dynamics.
Cardiovascular studies: In the field of cardiovascular research, Peptide5 is utilized to study the regulation of electrical conduction and tissue remodeling in the heart. Gap junctions, particularly those formed by Cx43, are crucial for the propagation of action potentials and maintenance of synchronized cardiac contractions. By modulating these intercellular channels, Peptide5 helps elucidate the mechanisms underlying arrhythmogenesis, myocardial injury response, and the progression of fibrotic changes. Its use has been instrumental in identifying potential molecular targets for improving cardiac function and mitigating adverse remodeling processes.
Inflammatory response modulation: The ability of Peptide5 to inhibit connexin43 hemichannels has significant implications for the study of inflammation. Uncontrolled hemichannel activity is associated with the release of pro-inflammatory mediators and the amplification of tissue injury. By dampening this signaling pathway, the peptide allows researchers to explore the regulation of cytokine release, leukocyte infiltration, and the resolution of inflammation in various tissue models. Its application supports the development of novel strategies for controlling excessive or chronic inflammatory responses at the cellular level.
Ophthalmic research: Peptide5 finds application in the study of ocular tissues, where gap junctions play a pivotal role in maintaining retinal integrity and function. Its selective action on Cx43 hemichannels is leveraged to investigate the contribution of intercellular communication to retinal health, photoreceptor survival, and the response to injury or degenerative stimuli. Researchers employ this peptide in both retinal cell cultures and organotypic models to uncover the molecular mechanisms governing visual signal transmission and the maintenance of retinal homeostasis.
Tissue repair and regeneration: The use of Peptide5 extends to research on wound healing and tissue regeneration, where connexin-mediated signaling is integral to cellular migration, proliferation, and coordination of repair processes. By transiently blocking gap junction communication, the peptide enables the study of how intercellular signaling influences the recruitment of repair cells, the deposition of extracellular matrix, and the restoration of tissue architecture. These investigations contribute to the broader understanding of regenerative biology and the potential to enhance tissue recovery following injury.
Peptide5 continues to support scientific discovery across a diverse range of research areas, offering a precise and reliable approach to modulating gap junction communication. Its application facilitates the dissection of complex cellular interactions in both health and disease, driving forward the exploration of intercellular signaling networks. As research into gap junction physiology and pathology advances, this peptide remains a critical tool for unraveling the molecular mechanisms underlying tissue function, cellular coordination, and adaptive responses.
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