Phoenixin-20 consists of a multi-residue sequence enriched with polar, hydrophobic, and aromatic segments that influence folding and binding. Researchers examine its dynamic conformational states across environments. The peptide supports studies of receptor-associated motifs. Applications span biophysical research, structural analysis, and ligand modeling.
CAT No: R2531
CAS No:1415039-77-8
Synonyms/Alias:Phoenixin-20;1415039-77-8;HY-P5763;DA-66676;CS-0891558;
Phoenixin-20 is a synthetic peptide that mirrors the structure of the endogenous neuropeptide phoenixin, which is derived from the C-terminal region of the small integral membrane protein 20 (SMIM20). As a bioactive peptide, it plays a significant role in neuroendocrine signaling and is recognized for its involvement in the modulation of reproductive function, appetite regulation, and stress response pathways. Its sequence and functional attributes have made it a valuable molecular tool for researchers investigating peptide-mediated signaling mechanisms and neuropeptide-receptor interactions in various physiological systems.
Receptor Binding Studies: Phoenixin-20 is widely utilized in receptor pharmacology research to elucidate the binding characteristics and downstream signaling of G protein-coupled receptors, particularly GPR173, which has been identified as its primary target. By employing this peptide in ligand-receptor binding assays, scientists can dissect the structural requirements for receptor activation, map binding domains, and characterize the specificity and affinity of neuropeptide-receptor interactions. Such studies are instrumental in advancing the understanding of neuropeptide signaling pathways and can inform the design of receptor-selective analogs for further functional exploration.
Neuroendocrine Regulation Research: In the context of neuroendocrinology, Phoenixin-20 serves as a model compound for investigating the molecular mechanisms underlying the regulation of gonadotropin-releasing hormone (GnRH) and other pituitary hormones. Experimental application of this peptide in in vitro and ex vivo systems enables the assessment of its effects on hormone secretion, signal transduction cascades, and feedback regulation within the hypothalamic-pituitary axis. These studies contribute to the broader comprehension of peptide-mediated hormonal control and the integration of neuroendocrine signals.
Behavioral and Appetite Studies: Researchers employ Phoenixin-20 to probe the central nervous system mechanisms that govern feeding behavior, satiety, and energy balance. By administering the peptide in animal models or neuronal culture systems, investigators can evaluate its influence on appetite modulation, food intake, and related neurobehavioral outcomes. These experimental approaches provide valuable insights into the role of neuropeptides in metabolic regulation and the neural circuitry involved in appetite control.
Stress and Anxiety Pathway Investigation: The peptide is also used in studies focused on the neurobiological basis of stress and anxiety responses. Phoenixin-20 has demonstrated modulatory effects on stress-related signaling pathways, making it a useful tool for examining how neuropeptides influence behavioral and physiological adaptations to stressors. Through controlled application in preclinical models, researchers can delineate the peptide's impact on neuroendocrine stress axes, neurotransmitter release, and behavioral phenotypes associated with anxiety.
Peptide Structure-Activity Relationship Analysis: In peptide chemistry and molecular pharmacology, Phoenixin-20 is employed as a reference molecule for the systematic investigation of structure-activity relationships (SAR). By synthesizing and testing a series of analogs or truncated variants, scientists can identify critical amino acid residues responsible for bioactivity, receptor selectivity, and metabolic stability. These SAR studies are essential for advancing rational peptide design and optimizing functional properties for research applications in neurobiology and endocrinology.
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