PNC-28, a highly influential and dominant bioactive peptide employed across the biomedical sector, showcases exceptional prowess in combating drug-resistant pathogens. Its undisputed efficacy has positioned it as a front-runner in the race against infectious diseases. Alleviating the precariousness of pathogenic survival, PNC-28 unleashes its potential by skillfully dismantling their cell membranes, effectively eliminating their existence. This extraordinary attribute of PNC-28 instills hope and potential for the advancement of revolutionary antimicrobial treatments, bestowing a brighter future upon humanity in its ongoing battle against microbial adversaries.
CAT No: R1983
CAS No:392661-17-5
Synonyms/Alias:PNC-28;392661-17-5;UNII-5237P710BP;5237P710BP;DA-56946;Glu-thr-phe-ser-asp-leu-trp-lys-leu-leu-lys-lys-trp-lys-met-arg-arg-asn-gln-phe-trp-val-lys-val-gln-arg-gly;
Chemical Name:(4S)-4-amino-5-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-5-carbamimidamido-1-(carboxymethylamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
PNC-28 is a synthetic peptide derived from a p53 protein sequence, engineered to harness tumor-suppressive properties for research applications in cellular signaling, apoptosis, and oncogenic pathway studies. As a bioactive peptide, it is distinguished by its ability to interact with molecular targets implicated in cancer biology, making it a valuable tool for probing mechanisms of cell death and tumor suppression. Its sequence and structural features enable selective modulation of protein-protein interactions, providing researchers with an effective model for investigating peptide-based interventions in oncological contexts. The compound's relevance extends to studies focused on peptide-membrane interactions, intracellular delivery mechanisms, and the exploration of novel therapeutic strategies at the preclinical research level.
Cancer biology research: PNC-28 is widely utilized in studies aimed at elucidating the molecular mechanisms underlying tumor suppression and apoptosis. By mimicking functional domains of the p53 tumor suppressor protein, the peptide allows researchers to dissect the pathways involved in programmed cell death and cellular stress responses. Its application in in vitro models facilitates the identification of downstream effectors and regulatory nodes critical to oncogenic transformation, thereby advancing the understanding of how peptide-based agents can influence cancer cell fate.
Peptide-membrane interaction studies: The unique amphipathic structure of this peptide supports investigations into its interaction with cellular membranes, particularly those of malignant cells. Researchers employ it to examine the biophysical properties of peptide-induced membrane disruption, permeability changes, and the selectivity of these effects for cancerous versus normal cells. Such studies provide valuable insights into the design of membrane-active peptides and the development of delivery systems that exploit differential membrane composition in pathological versus healthy tissues.
Protein-protein interaction analysis: PNC-28 serves as a model system for exploring the modulation of protein-protein interactions within the p53 signaling network. Its defined sequence allows for targeted studies on how peptides can disrupt or stabilize complexes involved in cell cycle regulation and apoptosis. This application is particularly relevant for high-throughput screening of peptide analogs or small molecules that may enhance or inhibit specific interactions, supporting the broader field of targeted molecular therapeutics research.
Cellular uptake and intracellular trafficking: The peptide's physicochemical properties make it an effective probe for studying mechanisms of peptide internalization and subcellular localization. Researchers utilize fluorescently labeled variants to track cellular uptake pathways, endosomal escape, and localization to organelles such as mitochondria. These studies are crucial for optimizing peptide delivery strategies and understanding the determinants of intracellular bioavailability, which inform the development of next-generation peptide-based research tools.
Peptide engineering and analog development: PNC-28 is frequently used as a template in the rational design and optimization of novel peptide analogs. Its well-characterized activity profile and defined structure-function relationships make it an ideal starting point for structure-activity relationship (SAR) studies, stability enhancements, and modification of bioactivity profiles. This application supports the advancement of peptide science by enabling the generation of new molecules with improved selectivity, stability, or functional properties for use in basic research and preclinical studies.
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