This is the pro-apoptotic peptide composed of D-amino acids, 5-FAM labeled. This alpha-helical amphipathic peptide is toxic to eukaryotic cells if internalized by a suitable targeting mechanism. It disrupts mitochondrial membranes upon receptor-mediated cell internalization and causes programmed cell death.
Peptide Library Construction and Screening
Powerful screening tools in biological and chemical research
M.W/Mr. | 1881.4 |
Sequence | One Letter Code: 5-FAM-klaklakklaklak-NH2 Three Letter Code: 5-FAM-D-Lys-D-Leu-D-Ala-D-Lys-D-Leu-D-Ala-D-Lys-D-Lys-D-Leu-D-Ala-D-Lys-D-Leu-D-Ala-D-Lys-NH2 |
References | 1. Marks, A. et al. Cancer Res. 65, 2373 (2005); 2. Kolonin, M. et al. Nat. Med. 10, 625 (2004). |
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