Prostate stem cell antigen; PSCA
CAT No: ta-537
Synonyms/Alias:Prostate stem cell antigen (105-133); PSCA (105-133)
PSCA (105-133) is a synthetic peptide corresponding to amino acids 105 through 133 of the Prostate Stem Cell Antigen (PSCA) protein, a glycosylphosphatidylinositol (GPI)-anchored cell surface antigen widely studied in the context of prostate and other epithelial tissues. As a peptide fragment derived from the C-terminal region of PSCA, it serves as a valuable molecular tool for investigating the structure, function, and immunological properties of the native protein. PSCA is known to be overexpressed in several malignancies, making its peptide derivatives important for research into tumor biology, cell signaling, and biomarker discovery. The defined sequence and biochemical properties of PSCA (105-133) facilitate its integration into a range of experimental systems, supporting advanced studies in molecular biology, immunology, and peptide-based assay development.
Epitope mapping: Researchers commonly utilize the PSCA (105-133) peptide for the identification and characterization of antibody binding sites within the PSCA protein. By serving as a defined antigenic fragment, it enables precise mapping of linear epitopes recognized by monoclonal or polyclonal antibodies, supporting the development and validation of immunoassays. Such studies are crucial for the generation of highly specific detection reagents and for understanding the immunogenic landscape of PSCA in various disease contexts.
Antibody production: The peptide is frequently employed as an immunogen for generating PSCA-specific antibodies in animal models. Its defined amino acid sequence allows for the elicitation of targeted immune responses, which can be harnessed to produce high-affinity antibodies for use in western blotting, immunohistochemistry, flow cytometry, and other immunodetection techniques. These antibodies are instrumental in probing PSCA expression patterns, cellular localization, and functional roles in both normal and pathological tissues.
Peptide-based assay development: In the context of assay design, PSCA (105-133) serves as a standard or calibrator in enzyme-linked immunosorbent assays (ELISA), bead-based multiplex platforms, and biosensor applications. Its well-characterized structure and reactivity enable the establishment of quantitative and qualitative assays for the detection of PSCA or anti-PSCA antibodies in biological samples. Such assays are essential for translational research, biomarker validation, and the monitoring of experimental interventions in preclinical models.
Cellular functional studies: The synthetic peptide can be used to investigate the biological activities associated with the C-terminal region of PSCA, including its potential roles in cell signaling, adhesion, and protein-protein interactions. By introducing the peptide into cultured cells or in vitro systems, researchers can dissect the contribution of this domain to cellular processes, signal transduction pathways, and interactions with extracellular ligands or receptors. These studies provide mechanistic insights into the functional significance of PSCA in health and disease.
Peptide synthesis and modification research: PSCA (105-133) is also valuable as a model substrate for studies focused on peptide synthesis, modification, and conjugation techniques. Its moderate length and defined sequence make it suitable for evaluating solid-phase peptide synthesis protocols, post-synthetic modifications such as labeling or glycosylation, and conjugation to carrier proteins or nanoparticles. Such work advances the development of peptide-based reagents, diagnostics, and research tools tailored to PSCA-related investigations.
1. An Open-label, Single-center, Safety and Efficacy Study of Eyelash Polygrowth Factor Serum
2. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
3. TMEM16F and dynamins control expansive plasma membrane reservoirs
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