PSMA-11 2,2,2-Trifluoroacetate presents a chelator-peptide conjugate that supports receptor-targeting and binding-affinity studies. Its multiple functional groups influence coordination geometry and solubility. Researchers evaluate conformational preferences across solvent systems. Uses include ligand-design testing, structural modeling, and targeted-peptide research.
CAT No: R2687
CAS No:2412149-32-5
Synonyms/Alias:PSMA-11 2,2,2-Trifluoroacetate;2412149-32-5;
PSMA-11 2,2,2-Trifluoroacetate is a synthetic peptide derivative widely recognized for its high affinity and specificity toward the prostate-specific membrane antigen (PSMA), a cell surface protein overexpressed in prostate cancer and certain other malignancies. As a chemically defined peptide conjugate, PSMA-11 serves as a critical molecular tool in the development and validation of targeted imaging agents, radioligand platforms, and biochemical assays. Its unique structure, incorporating a urea-based motif and a chelator-compatible backbone, makes it particularly valuable for applications requiring selective PSMA recognition and stable conjugation with diagnostic or analytical moieties. The trifluoroacetate form ensures solubility and stability, facilitating reliable handling in laboratory and industrial workflows.
Targeted imaging agent development: In preclinical research, PSMA-11 derivatives are extensively employed as precursors or reference standards for the synthesis of PSMA-targeted imaging probes. By enabling site-specific conjugation with chelators such as DOTA or HBED-CC, these peptide constructs facilitate the creation of radiolabeled ligands suitable for positron emission tomography (PET) and single-photon emission computed tomography (SPECT) studies. Such probes are instrumental in visualizing PSMA expression patterns in cell lines, tissue samples, and animal models, supporting the optimization of imaging protocols and the evaluation of new radiotracers for cancer research.
Ligand-receptor interaction studies: The high binding affinity of PSMA-11 for its target enables detailed investigation of ligand-receptor dynamics, including binding kinetics, specificity, and competitive inhibition. Researchers utilize this peptide to characterize PSMA's molecular interactions, assess structure-activity relationships, and validate new analogs or inhibitors. These studies provide critical insights into the biochemical mechanisms underlying PSMA recognition and inform the rational design of next-generation targeting agents.
Cell-based assay development: PSMA-11 and its derivatives are frequently used to establish and validate cell-based assays that quantify PSMA expression, internalization, and trafficking. By serving as a well-characterized ligand, it allows for the standardization of experimental conditions in flow cytometry, fluorescence microscopy, and receptor quantification platforms. Such assays are essential for screening PSMA-targeted compounds, monitoring receptor modulation, and elucidating cellular uptake mechanisms in vitro.
Analytical method calibration: As a structurally defined reference compound, PSMA-11 2,2,2-Trifluoroacetate plays a pivotal role in the calibration and validation of analytical methods, including high-performance liquid chromatography (HPLC) and mass spectrometry. Its use ensures accurate quantification, purity assessment, and stability testing of PSMA-targeted peptides and conjugates. Reliable analytical standards are vital for quality control in peptide synthesis, formulation development, and regulatory documentation in research settings.
Peptide synthesis and conjugation research: The robust chemical framework of PSMA-11 supports its utility as a model substrate for peptide synthesis optimization and bioconjugation studies. Researchers leverage its functional groups and chelator-ready backbone to explore new synthetic routes, coupling strategies, and site-specific labeling techniques. These investigations advance the development of modular peptide platforms and facilitate the integration of imaging, therapeutic, or reporter functionalities for a broad range of biochemical and translational research applications.
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