PSMA-11 2,2,2-Trifluoroacetate presents a chelator-peptide conjugate that supports receptor-targeting and binding-affinity studies. Its multiple functional groups influence coordination geometry and solubility. Researchers evaluate conformational preferences across solvent systems. Uses include ligand-design testing, structural modeling, and targeted-peptide research.
CAT No: R2687
CAS No:2412149-32-5
Synonyms/Alias:PSMA-11 2,2,2-Trifluoroacetate;2412149-32-5;
PSMA-11 2,2,2-Trifluoroacetate is a specialized carbohydrate conjugate widely recognized in the scientific community for its pivotal role in molecular imaging and targeted research applications. As a derivative of PSMA-11, this compound incorporates a 2,2,2-trifluoroacetate moiety, which enhances its chemical stability and solubility, facilitating efficient handling in laboratory settings. The unique structure of PSMA-11 2,2,2-Trifluoroacetate enables it to function as a high-affinity ligand for prostate-specific membrane antigen (PSMA), a cell surface protein overexpressed in certain pathological conditions. Its adaptability and robust binding characteristics make it an invaluable tool for researchers seeking precision and reliability in their investigative protocols. The compound's compatibility with various labeling strategies further broadens its utility across multiple scientific disciplines, supporting advanced studies in molecular targeting, imaging agent development, and biochemical analysis.
Molecular Imaging Research: PSMA-11 2,2,2-Trifluoroacetate is extensively utilized in the field of molecular imaging, where its strong affinity for PSMA allows for the selective visualization of target cells. Researchers employ this compound in the synthesis of radiolabeled tracers, which, when introduced into biological systems, bind specifically to PSMA-expressing tissues. This targeted approach enables the generation of high-contrast images, supporting the identification and monitoring of cellular processes at the molecular level. The compound's stability and ease of conjugation with imaging isotopes are key factors that drive its widespread adoption in preclinical imaging studies.
Radiopharmaceutical Development: The PSMA-11 carbohydrate conjugate serves as a foundational building block in the development of novel radiopharmaceuticals. Its ability to be readily modified with a variety of radionuclides enables scientists to tailor imaging agents for specific research objectives. By leveraging the high selectivity of PSMA-11 derivatives, researchers can design targeted radiotracers that provide precise biodistribution data, facilitating the study of biological pathways and disease progression. The trifluoroacetate form further enhances the compound's shelf-life and handling, streamlining the synthesis and storage of radiopharmaceutical candidates.
Targeted Drug Delivery Research: The unique ligand properties of PSMA-11 2,2,2-Trifluoroacetate make it an attractive component in targeted drug delivery system design. By exploiting its high binding affinity, researchers can develop conjugates that direct therapeutic agents specifically to PSMA-expressing cells. This targeted delivery approach holds promise for improving the selectivity and efficacy of experimental therapeutics while minimizing off-target effects. The trifluoroacetate group facilitates the preparation of stable conjugates, ensuring consistent performance in cell-based assays and in vivo studies.
Bioconjugation and Labeling Studies: Scientists frequently employ PSMA-11 derivatives in bioconjugation and labeling experiments, where precise attachment of functional groups or reporter molecules is essential. The chemical attributes of the trifluoroacetate salt allow for straightforward modification and coupling reactions, supporting the creation of diverse conjugates for use in analytical assays. This versatility is particularly valuable in the development of customized probes for fluorescence imaging, flow cytometry, or affinity purification applications, where specificity and reproducibility are paramount.
Biochemical Pathway Investigation: PSMA-11 2,2,2-Trifluoroacetate also finds application in the exploration of biochemical pathways involving PSMA or related proteins. By serving as a molecular probe, it enables the detailed analysis of protein-ligand interactions, receptor dynamics, and cellular uptake mechanisms. This information is critical for advancing the understanding of PSMA biology and for identifying new targets for molecular intervention. The compound's robust performance in various biochemical assays underscores its value as a research tool in functional studies of cell surface proteins and their physiological roles.
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