Rusalatide acetate (TP508 amide acetate), a regenerative peptide, mitigates radiation-induced gastrointestinal damage by activating stem cells and preserving crypt integrity.
CAT No: R1662
CAS No:875455-82-6
Synonyms/Alias:Chrysalin;Rusalatide acetate;875455-82-6;Rusalatide acetate [USAN];TP508;TRAP 508;UNII-9J556O9JPD;9J556O9JPD;TP 508;TRAP-508;Rusalatide acetate (USAN);TP508 amide acetate;TP-508 ACETATE;TRAP-508 ACETATE;Rusalatide acetate (3:2);L-Valinamide, L-alanylglycyl-L-tyrosyl-L-lysyl-L-prolyl-L-alpha-aspartyl-L-alpha- glutamylglycyl-L-lysyl-L-arginylglycyl-L-alpha-aspartyl-L-alanyl-L-cysteinyl-L-alpha- glutamylglycyl-L-alpha-aspartyl-L-serylglycylglycyl-L-prolyl-L-phenylalanyl-, acetate (3:2) (salt);Chrysalin (TN);RUSALATIDE ACETATE (3:2) [MI];DA-77590;ALA-GLY-TYR-LYS-PRO-ASP-GLU-GLY-LYS-ARG-GLY-ASP-ALA-CYS-GLU-GLY-ASP-SER-GLY-GLY-PRO-PHE-VAL ACETATE;
Rusalatide acetate is a synthetic peptide compound that has garnered significant attention in the field of biochemical research due to its unique sequence and properties. As a member of the peptide class, it is characterized by a defined amino acid arrangement that imparts specific biological activities relevant to cellular signaling and protein interaction studies. The compound's structure enables it to serve as a valuable tool in the investigation of peptide-mediated mechanisms, making it an important asset for research teams focused on understanding complex biochemical pathways and developing new methodologies in peptide science.
Peptide signaling research: Rusalatide acetate is widely utilized in studies aimed at deciphering peptide-based signaling pathways. Its defined amino acid sequence allows researchers to probe the mechanisms by which peptides interact with cellular receptors, modulate intracellular cascades, and influence physiological processes at the molecular level. By employing this compound in receptor binding assays or signal transduction experiments, scientists can gain insights into the specificity and dynamics of peptide-receptor interactions, which are foundational to many areas of molecular biology and pharmacology.
Protein interaction analysis: The compound serves as a robust probe for investigating protein-protein interactions, particularly those involving short peptide motifs. Its synthetic origin and stability make it ideal for use in affinity purification, pull-down assays, and surface plasmon resonance studies. Through these applications, researchers can map binding sites, characterize interaction partners, and elucidate the structural determinants that govern molecular recognition events, thereby advancing the understanding of protein networks and complexes.
Peptide synthesis validation: Rusalatide acetate is frequently employed as a standard or reference material in the development and optimization of solid-phase peptide synthesis protocols. Its well-characterized structure and predictable chromatographic behavior facilitate the calibration of analytical instruments and the validation of synthesis methodologies. By benchmarking synthetic yields and purity against this compound, laboratories can improve the reliability and reproducibility of peptide production processes, which is critical for both research and industrial applications.
Cellular functional assays: In functional studies, rusalatide-derived peptides are introduced into cellular models to assess their effects on cell signaling, proliferation, or differentiation. These assays help delineate the bioactivity of peptide motifs and their influence on cellular physiology. The compound's stability and compatibility with various assay formats make it a preferred choice for researchers seeking to explore the functional consequences of peptide exposure in vitro, contributing valuable data to the field of cell biology.
Analytical method development: Rusalatide acetate is also applied in the development and refinement of analytical techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry. Its distinct physicochemical properties make it suitable as a performance marker for method calibration, sensitivity testing, and system suitability assessments. By incorporating this peptide into analytical workflows, laboratories can ensure the accuracy and consistency of peptide quantification and characterization, supporting high-quality data generation for complex biological samples.
2. TMEM16F and dynamins control expansive plasma membrane reservoirs
5. Cationic cell-penetrating peptides are potent furin inhibitors
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