(Sar1,Ile4·8)-Angiotensin II contains a sarcosine substitution at position 1 and isoleucine at positions 4 and 8, fine-tuning the peptide's receptor-binding profile and stability. The structural changes modify the peptide's hydrophobicity and receptor affinity. This variant is employed in studies of angiotensin II receptor signaling, focusing on vasoconstriction and blood pressure regulation. Researchers use it to dissect sequence requirements for angiotensin-induced signaling.
CAT No: A15076
CAS No:185461-45-4
Synonyms/Alias:(Sar1,Ile4,8)-Angiotensin II;185461-45-4;(2S,3S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-5-(Diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-methylpentanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoic acid;HY-P4685;PD133153;CS-0655957;(2S,3S)-2-{[(2S)-1-[(2S)-2-[(2S,3S)-2-[(2S,3S)-2-[(2S)-2-[(2S)-5-carbamimidamido-2-[2-(methylamino)acetamido]pentanamido]-3-methylbutanamido]-3-methylpentanamido]-3-methylpentanamido]-3-(1H-imidazol-4-yl)propanoyl]pyrrolidin-2-yl]formamido}-3-methylpentanoic acid;
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