(Sar1,Tyr(Me)4)-Angiotensin II incorporates a sarcosine at position 1 and a methylated tyrosine at position 4 to enhance receptor selectivity and stability. These substitutions help modulate peptide activity and receptor interaction, influencing vasoconstriction and blood pressure regulation. Researchers apply this variant in studies of angiotensin receptor subtype specificity and pharmacological profiling.
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