Senktide is shown to selectively interact with a tachykinin receptor subtype (SP-N) and can be used in studies to find out the regulation, distribution, and functional role of this receptor. This compound is also reported to be an NK-3R agonist and may cause behavior similar to serotonergic stimulation in murine models.
CAT No: R1840
CAS No:106128-89-6
Synonyms/Alias:Senktide;106128-89-6;189261-10-7;Succinyl-6-asp-8-Me-phe-substance P (6-11);Substance P (6-11), succinyl-asp(6)-Me-phe(8)-;CHEMBL106124;suc[Asp6,MePhe3]SP(6-11);Substance P (6-11), succinyl-aspartyl(6)-methylphenylalanine(8)-;suc[Asp6,MePhe3]SP(6-11));(5S,8S,14S,17S,20S)-14,17-Dibenzyl-5-carbamoyl-20-(carboxymethyl)-8-isobutyl-15-methyl-7,10,13,16,19,22-hexaoxo-2-thia-6,9,12,15,18,21-hexaazapentacosan-25-oic acid;(3S)-4-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]amino]-3-[(4-hydroxy-4-oxobutanoyl)amino]-4-oxobutanoic acid;4-10-Neuromedin B (swine spinal cord), N-(3-carboxy-1-oxopropyl)-6-(N-methyl-L-phenylalanine)-7-de-L-valine-;L-Methioninamide, N-(3-carboxy-1-oxopropyl)-L-alpha-aspartyl-L-phenylalanyl-N-methyl-L-phenylalanylglycyl-L-leucyl-;N-(3-Carboxy-1-oxopropyl)-6-(N-methyl-L-phenylalanine)-7-de-L-valine-4-10-neuromedin B (swine spinal cord);Succinyl-(Asp6,N-Me-Phe8)-Substance P (6-11);suc(Asp6,MePhe3)SP(6-11);suc(Asp6,MePhe3)SP(6-11));(3S)-4-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(3-carboxypropanoylamino)-4-oxobutanoic acid;(3S)-4-(((2S)-1-(((2S)-1-((2-(((2S)-1-(((2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)-methylamino)-1-oxo-3-phenylpropan-2-yl)amino)-3-((4-hydroxy-4-oxobutanoyl)amino)-4-oxobutanoic acid;GTPL2127;SCHEMBL5238634;DTXSID80909926;HMHYXLVEFVGOPM-QKUYTOGTSA-N;HY-P0187;BDBM50052524;CS-8091;DA-56013;DA-78081;FS109556;MS-31559;G12250;Q27088780;Suc-Asp-Phe-N-Me-Phe-Gly-Leu-Met-NH2; H-(Suc)DF(NMeF)GLM-NH2;(S)-N-((S)-1-{[(S)-1-({[(S)-1-((S)-1-Carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethyl]-methyl-carbamoyl}-2-phenyl-ethyl)-3-(3-carboxy-propionylamino)-succinamic acid;4-({14-Benzyl-7,10,13-trihydroxy-5-[hydroxy(imino)methyl]-15-methyl-8-(2-methylpropyl)-16-oxo-18-phenyl-2-thia-6,9,12,15-tetraazaoctadeca-6,9,12-trien-17-yl}imino)-3-[(3-carboxy-1-hydroxypropylidene)amino]-4-hydroxybutanoic acid;
Chemical Name:N-(3-carboxy-1-oxopropyl)-L-α-aspartyl-L-phenylalanyl-N-methyl-L-phenylalanylglycyl-L-leucyl-L-methioninamide
Senktide is a synthetic peptide compound recognized for its potent and selective agonist activity at neurokinin-3 (NK3) receptors. Structurally derived from the tachykinin peptide family, it features modifications that enhance receptor specificity and metabolic stability, making it a valuable biochemical tool for neuropharmacological research. The compound's ability to mimic endogenous neurokinins allows investigators to dissect signaling pathways mediated by NK3 receptors, which play crucial roles in neuroendocrine regulation, neurotransmission, and various physiological processes. Its unique pharmacological profile has established it as a preferred agent for probing tachykinin receptor function in both in vitro and in vivo experimental systems.
Receptor Pharmacology Studies: Senktide is extensively utilized in receptor characterization assays to elucidate the functional roles of NK3 receptors in neuronal and non-neuronal tissues. By selectively activating these receptors, researchers can differentiate NK3-mediated responses from those triggered by other tachykinin subtypes, such as NK1 and NK2. This selectivity is instrumental in mapping receptor distribution, quantifying ligand-receptor interactions, and understanding the molecular determinants of receptor activation and signaling cascades in diverse biological models.
Neuroendocrine Research: In neuroendocrinology, senktide serves as a reliable probe to investigate the regulatory mechanisms governing hormone secretion and hypothalamic-pituitary axis function. Its ability to stimulate NK3 receptors enables precise modulation of neuropeptide release, facilitating studies on gonadotropin-releasing hormone (GnRH) neurons, reproductive axis regulation, and the integration of neuroendocrine signals. Such applications are critical for advancing knowledge of hormone feedback loops and their physiological implications in animal models.
Neuroscience and Synaptic Transmission: The compound is widely employed to explore the role of tachykinin signaling in synaptic transmission and neural circuit modulation. By applying senktide to cultured neurons or brain tissue slices, investigators can assess its effects on neurotransmitter release, neuronal excitability, and synaptic plasticity. These experiments provide insight into how NK3 receptor activation influences central nervous system processes, including pain perception, stress responses, and behavioral outcomes.
Signal Transduction Pathway Analysis: Senktide offers a controlled means to activate intracellular signaling pathways downstream of NK3 receptor engagement. Researchers leverage this property to study G-protein coupled receptor (GPCR) signaling, second messenger generation, and kinase activation in various cell types. Such mechanistic studies are essential for delineating the molecular events that underlie tachykinin-mediated cellular responses, supporting the development of novel pharmacological modulators and enhancing the understanding of GPCR biology.
Peptide Drug Discovery and Development: As a structurally optimized tachykinin analog, senktide is valuable in the context of peptide-based drug discovery. Its high specificity and stability make it a reference ligand for screening novel NK3 receptor modulators, benchmarking peptide analogs, and evaluating structure-activity relationships. These applications contribute to the rational design of new research tools and potential therapeutic candidates targeting tachykinin pathways, thereby supporting innovation in neuropeptide science and pharmacology.
3. The spatiotemporal control of signalling and trafficking of the GLP-1R
4. High fat diet and GLP-1 drugs induce pancreatic injury in mice
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