Senktide

Name: Senktide
Brand: Creative Peptides
SKU: R1840
Availability: MadeToOrder

Senktide is shown to selectively interact with a tachykinin receptor subtype (SP-N) and can be used in studies to find out the regulation, distribution, and functional role of this receptor. This compound is also reported to be an NK-3R agonist and may cause behavior similar to serotonergic stimulation in murine models.

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CAT No: R1840

CAS No: 106128-89-6

Synonyms/Alias: Senktide;106128-89-6;189261-10-7;Succinyl-6-asp-8-Me-phe-substance P (6-11);Substance P (6-11), succinyl-asp(6)-Me-phe(8)-;CHEMBL106124;suc[Asp6,MePhe3]SP(6-11);Substance P (6-11), succinyl-aspartyl(6)-methylphenylalanine(8)-;suc[Asp6,MePhe3]SP(6-11));(5S,8S,14S,17S,20S)-14,17-Dibenzyl-5-carbamoyl-20-(carboxymethyl)-8-isobutyl-15-methyl-7,10,13,16,19,22-hexaoxo-2-thia-6,9,12,15,18,21-hexaazapentacosan-25-oic acid;(3S)-4-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]amino]-3-[(4-hydroxy-4-oxobutanoyl)amino]-4-oxobutanoic acid;4-10-Neuromedin B (swine spinal cord), N-(3-carboxy-1-oxopropyl)-6-(N-methyl-L-phenylalanine)-7-de-L-valine-;L-Methioninamide, N-(3-carboxy-1-oxopropyl)-L-alpha-aspartyl-L-phenylalanyl-N-methyl-L-phenylalanylglycyl-L-leucyl-;N-(3-Carboxy-1-oxopropyl)-6-(N-methyl-L-phenylalanine)-7-de-L-valine-4-10-neuromedin B (swine spinal cord);Succinyl-(Asp6,N-Me-Phe8)-Substance P (6-11);suc(Asp6,MePhe3)SP(6-11);suc(Asp6,MePhe3)SP(6-11));(3S)-4-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]-methylamino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(3-carboxypropanoylamino)-4-oxobutanoic acid;(3S)-4-(((2S)-1-(((2S)-1-((2-(((2S)-1-(((2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)-methylamino)-1-oxo-3-phenylpropan-2-yl)amino)-3-((4-hydroxy-4-oxobutanoyl)amino)-4-oxobutanoic acid;GTPL2127;SCHEMBL5238634;DTXSID80909926;HMHYXLVEFVGOPM-QKUYTOGTSA-N;HY-P0187;BDBM50052524;CS-8091;DA-56013;DA-78081;FS109556;MS-31559;G12250;Q27088780;Suc-Asp-Phe-N-Me-Phe-Gly-Leu-Met-NH2; H-(Suc)DF(NMeF)GLM-NH2;(S)-N-((S)-1-{[(S)-1-({[(S)-1-((S)-1-Carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethyl]-methyl-carbamoyl}-2-phenyl-ethyl)-3-(3-carboxy-propionylamino)-succinamic acid;4-({14-Benzyl-7,10,13-trihydroxy-5-[hydroxy(imino)methyl]-15-methyl-8-(2-methylpropyl)-16-oxo-18-phenyl-2-thia-6,9,12,15-tetraazaoctadeca-6,9,12-trien-17-yl}imino)-3-[(3-carboxy-1-hydroxypropylidene)amino]-4-hydroxybutanoic acid;

Chemical Name: N-(3-carboxy-1-oxopropyl)-L-α-aspartyl-L-phenylalanyl-N-methyl-L-phenylalanylglycyl-L-leucyl-L-methioninamide

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Specification Technical Data Publications Customer reviews and Q&A

M.F/Formula	C40H55N7O11S
M.W/Mr.	842
Sequence	One Letter Code:DFFGLM Three Letter Code:Suc-Asp-Phe-N(Me)Phe-Gly-Leu-Met-NH2
Purity	>97% (by HPLC)
Activity	NK3 tachykinin receptor agonist. Causes direct excitation of dopamine neurons; enhances dopaminergic function. Induces locomotor activity.

Long-term Storage Conditions	Soluble to 1 mg/ml in PBS (pH 7.4)
Shipping Condition	Shipped at room temperature
InChI	InChI=1S/C40H55N7O11S/c1-24(2)19-28(37(55)45-27(36(41)54)17-18-59-4)44-33(49)23-42-39(57)31(21-26-13-9-6-10-14-26)47(3)40(58)30(20-25-11-7-5-8-12-25)46-38(56)29(22-35(52)53)43-32(48)15-16-34(50)51/h5-14,24,27-31H,15-23H2,1-4H3,(H2,41,54)(H,42,57)(H,43,48)(H,44,49)(H,45,55)(H,46,56)(H,50,51)(H,52,53)/t27-,28-,29-,30-,31-/m0/s1
InChI Key	HMHYXLVEFVGOPM-QKUYTOGTSA-N
Canonical SMILES	CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(CC1=CC=CC=C1)N(C)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)O)NC(=O)CCC(=O)O
Isomeric SMILES	CC(C)C[C@@H](C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)N(C)C(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(=O)O)NC(=O)CCC(=O)O

1. Identification, Localization in the Central Nervous System and Novel Myostimulatory Effect of Allatostatins in Tenebrio molitor Beetle

3. Cell-based adhesion assays for isolation of snake venom’s integrin antagonists

4. Novel Peptide-Based PD1 Immunomodulators Demonstrate Efficacy in Infectious Disease Vaccines and Therapeutics

5. Tachykinin-related peptides modulate immune-gene expression in the mealworm beetle Tenebrio molitor L

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