Slu-PP-332 offers a modular peptide framework designed to probe binding equilibria and structural motifs. Residue diversity shapes hydrophobic, aromatic, and polar interactions. Researchers explore its conformational states across solvent systems. Use includes peptide optimization, structural biology, and motif-function studies.
CAT No: R2657
CAS No:303760-60-3
Synonyms/Alias:SLU-PP-332;4-Hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide;CHEMBL4208749;303760-60-3;(E)-4-Hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide;SCHEMBL12937827;BDBM50455424;STK082756;AKOS000484286;HY-155673;CS-0884590;4-hydroxy-N'-[(E)-naphthalen-2-ylmethylidene]benzohydrazide;
Slu-PP-332 is a synthetic small molecule compound recognized for its role as a selective modulator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pump. As a member of the SERCA modulator class, Slu-PP-332 offers researchers a valuable tool for investigating calcium homeostasis, cellular signaling, and the intricate regulation of calcium-dependent physiological processes. Its unique biochemical profile allows for precise manipulation of intracellular calcium dynamics, making it particularly relevant in studies focused on muscle contraction, metabolic regulation, and endoplasmic reticulum (ER) function. The compound's specificity and potency have positioned it as a preferred agent in mechanistic studies of calcium transport and related cellular pathways.
Calcium signaling research: Slu-PP-332 serves as a powerful probe for dissecting the mechanisms underlying calcium signaling in a variety of cell types. By selectively modulating SERCA activity, it allows researchers to analyze the kinetics of calcium uptake into the ER, assess the impact of altered calcium storage on downstream signaling cascades, and elucidate the role of calcium flux in physiological and pathological states. Its application is particularly valuable in studies aiming to understand the temporal and spatial aspects of calcium-dependent signal transduction.
Muscle physiology studies: The regulation of SERCA is central to muscle contraction and relaxation cycles. Slu-PP-332 is widely utilized to investigate the effects of altered SERCA function on skeletal and cardiac muscle physiology. By modulating calcium reuptake into the sarcoplasmic reticulum, the compound enables detailed examination of excitation-contraction coupling, muscle fatigue, and adaptation processes. These insights are essential for advancing knowledge of muscular disorders and the fundamental biology of contractile tissues.
Endoplasmic reticulum stress modeling: Disruption of ER calcium homeostasis is a key factor in the induction of ER stress and the unfolded protein response. Slu-PP-332 provides researchers with a precise means to manipulate ER calcium levels, facilitating the creation of experimental models to study ER stress signaling pathways. This application is instrumental for exploring the molecular events that link calcium dysregulation to protein misfolding, cellular stress responses, and downstream effects on cell survival and function.
Metabolic regulation investigations: Calcium flux through SERCA plays a critical role in cellular energy metabolism and bioenergetics. The use of Slu-PP-332 in metabolic studies enables the characterization of how altered ER calcium handling influences metabolic enzyme activity, mitochondrial function, and ATP production. Researchers leverage this compound to probe the interplay between calcium homeostasis and metabolic control, providing insights into the integration of signaling and energy pathways at the cellular level.
High-throughput screening and assay development: The specificity and tunable activity of Slu-PP-332 make it suitable for use in high-throughput screening platforms designed to identify novel SERCA modulators or to assess the impact of genetic or pharmacological interventions on calcium handling. Its application in assay development supports the establishment of robust, reproducible models for drug discovery, mechanistic studies, and the evaluation of compound libraries targeting calcium transport mechanisms. This utility underlines its value as a reference compound in both academic and industrial research settings.
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