SN50, also named NF-KB inhibitor, is a synthetic peptide corresponding to the nuclear localization sequence of NF-KB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells. It blocks the nuclear import of p105 in cells treated with activators of NF-KB signaling, including LPS and TNF-Alpha.
CAT No: R1845
CAS No:213546-53-3
Synonyms/Alias:SN50;213546-53-3;NFkappaB Inhibitor;NF-kappaB Inhibitor, SN50;H-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-VAL-GLN-ARG-LYS-ARG-GLN-LYS-LEU-MET-PRO-OH;NF-kappaB SN50;SN50 trifluoroacetate salt;AAVALLPAVLLALLAPVQRKRQKLMP;CHEBI:195371;SN 50;SN-50;H-AAVALLPAVLLALLAPVQRKRQKLMP-OH;AKOS040738511;DA-57948;FN109704;G12952;Nuclear Factor NF-KB Inhibitor SN50 trifluoroacetate salt;H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln- Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH; H-AAVALLPAVLLALLAPVQR KRQKLMP-OH;L-Ala-L-Ala-L-Val-L-Ala-L-Leu-L-Leu-L-Pro-L-Ala-L-Val-L-Leu-L-Leu-L-Ala-L-Leu-L-Leu-L-Ala-L-Pro-L-Val-L-Gln-L-Arg-L-Lys-L-Arg-L-Gln-L-Lys-L-Leu-L-Met-L-Pro;L-alanyl-L-alanyl-L-valyl-L-alanyl-L-leucyl-L-leucyl-L-prolyl-L-alanyl-L-valyl-L-leucyl-L-leucyl-L-alanyl-L-leucyl-L-leucyl-L-alanyl-L-prolyl-L-valyl-L-glutaminyl-L-arginyl-L-lysyl-L-arginyl-L-glutaminyl-L-lysyl-L-leucyl-L-methionyl-L-proline;
1. Low bone turnover and low BMD in Down syndrome: effect of intermittent PTH treatment
3. TMEM16F and dynamins control expansive plasma membrane reservoirs
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