SN50

Tetracosactide is a synthetic peptide, which corresponds to the first 24 amino acids of the naturally occurring hormone ACTH (adrenocorticotropic hormone). It stimulates the adrenal cortex to produce corticosteroids, mineralocorticoids, and, to a lesser extent, androgens.

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CAT#R1845
ExplanationSN50, also named NF-KB inhibitor, is a synthetic peptide corresponding to the nuclear localization sequence of NF-KB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells. It blocks the nuclear import of p105 in cells treated with activators of NF-KB signaling, including LPS and TNF-Alpha.
Synonyms/AliasNuclear Factor NF-KB Inhibitor SN50; NFkappaB Inhibitor
M.F/FormulaC129H230N36O29S
M.W/Mr.2781.5
SequenceOne Letter Code: AAVALLPAVLALLAPVQRKRQKLMP
Three Letter Code: Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro
ApplicationThis peptide is commonly used to evaluate the role of NF-KB signaling in cellular responses.
AppearanceLyophilized solid
Purity≥97% by HPLC
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