SN50, also named NF-KB inhibitor, is a synthetic peptide corresponding to the nuclear localization sequence of NF-KB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells. It blocks the nuclear import of p105 in cells treated with activators of NF-KB signaling, including LPS and TNF-Alpha.
CAT# | R1845 |
CAS | 213546-53-3 |
Synonyms/Alias | Nuclear Factor NF-KB Inhibitor SN50; NFkappaB Inhibitor |
M.F/Formula | C129H230N36O29S |
M.W/Mr. | 2781.5 |
Sequence | One Letter Code: AAVALLPAVLALLAPVQRKRQKLMP Three Letter Code: Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro |
Application | This peptide is commonly used to evaluate the role of NF-KB signaling in cellular responses. |
Appearance | Lyophilized solid |
Purity | ≥97% by HPLC |
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