Substance P (7-11) is a C-terminal fragment of Substance P which can cause an increase in the intracellular calcium concentration.
CAT No: R1694
CAS No:51165-05-0
Synonyms/Alias:Substance P (7-11);51165-05-0;H-Phe-Phe-Gly-Leu-Met-NH2;Substance P(7-11);SP(7-11);FFGLM-NH2;Phe-Phe-Gly-Leu-Met-NH2;(2S)-N-[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]-2-[[2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-4-methylpentanamide;CHEBI:191176;L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2;L-Methioninamide, L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-;L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-methioninamide;DTXSID70965435;HY-P1492;Phe1-Phe2-Gly3-Leu4-Met5-NH2;DA-58141;CS-0044448;G12251;(S)-2-(2-((S)-2-((S)-2-amino-3-phenylpropanamido)-3-phenylpropanamido)acetamido)-N-((S)-1-amino-4-(methylthio)-1-oxobutan-2-yl)-4-methylpentanamide;14-Amino-11-benzyl-4,7,10,13-tetrahydroxy-5-(2-methylpropyl)-2-[2-(methylsulfanyl)ethyl]-15-phenyl-3,6,9,12-tetraazapentadeca-3,6,9,12-tetraen-1-imidic acid;
Substance P 7-11 is a synthetic peptide fragment corresponding to the C-terminal pentapeptide sequence of the neuropeptide Substance P. As a biologically active segment, it retains key functional motifs responsible for many of the parent molecule's receptor interactions, particularly with the neurokinin-1 (NK1) receptor. Its defined sequence and manageable size make it a valuable tool for dissecting the structure-activity relationships of Substance P and for probing the molecular basis of neuropeptide signaling. Researchers working in neurobiology, peptide pharmacology, and cellular signaling frequently utilize this fragment to study mechanisms underlying neurotransmission, pain modulation, and neuroinflammatory processes.
Receptor binding studies: Substance P 7-11 serves as a focused probe for evaluating the binding specificity and affinity of neurokinin receptors, especially the NK1 subtype. Its use in receptor-ligand binding assays allows researchers to map the minimal sequence requirements for receptor activation and to distinguish between full-length and truncated peptide interactions. This application is fundamental in elucidating the molecular determinants of neuropeptide-receptor recognition and in guiding the rational design of selective receptor modulators.
Peptide structure-activity relationship (SAR) analysis: The pentapeptide fragment is widely employed in SAR studies to assess how truncation or modification of the Substance P sequence influences biological activity. By comparing the functional effects of Substance P 7-11 with those of the full-length peptide and other fragments, scientists can identify critical residues for receptor activation, signal transduction, and downstream cellular responses. These insights help clarify the essential structural features required for neuropeptide efficacy and selectivity.
Neuropharmacological research: In neuropharmacology, Substance P 7-11 is utilized to investigate the role of C-terminal sequences in modulating synaptic transmission and neuropeptide-mediated signaling pathways. Its application in in vitro and ex vivo systems enables the dissection of peptide-induced effects on neuronal excitability, neurotransmitter release, and second messenger cascades. Such studies are instrumental in advancing the understanding of neuropeptide function in both normal and pathological neural circuits.
Peptide synthesis and method development: The defined sequence and manageable length of Substance P 7-11 make it a practical standard in peptide synthesis laboratories. It is often used as a reference compound to optimize solid-phase peptide synthesis protocols, assess coupling efficiencies, and validate purification strategies. Its consistent performance in analytical and preparative workflows supports the development of robust methodologies for the production and characterization of bioactive peptides.
Analytical assay calibration: Substance P 7-11 is also employed as a calibration standard in quantitative analytical techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry. Its well-characterized physicochemical properties facilitate method validation, instrument calibration, and the establishment of accurate detection parameters. This role is essential for ensuring reproducibility and reliability in peptide quantification and for supporting high-quality analytical research in neuropeptide chemistry.
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