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Substance P

Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator.The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: R1691

CAS No:33507-63-0

Synonyms/Alias:Substance P;33507-63-0;Neurokinin P;Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2;CCRIS 7229;Substance P acetate salt;EINECS 251-545-8;Neuropeptide sp-1;Sh-oligopeptide-73;Substance p (1-11);675VGV5J1D;CHEMBL235363;12769-48-1;ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 3ACOH 5H2O;11035-08-8;C63H98N18O13S;UNII-675VGV5J1D;substance-P;Substanz-P;Neurokinin-1;Substance P?;Neurokinin P TFA;[3H]-substance P;Substance P (smooth-muscle stimulant);[125I]-substance P;137348-11-9;Euler Gaddum Substance P;Euler-Gaddum Substance P;SUBSTANCE P [MI];Substance P, Euler-Gaddum;tachykinin substance P (SP);GTPL2098;GTPL3805;GTPL3835;H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2;SCHEMBL1116347;[3H]SP (human, mouse, rat);SCHEMBL20844802;CHEBI:80308;[3H]-SP;ArgProLysProGlnGlnPhePheGlyLeuMet;[125I]SP (human, mouse, rat);SH-OLIGOPEPTIDE-73 [INCI];[125I]-SP;BDBM50001450;HB2915;AKOS024456424;FS73619;NCGC00167123-01;AS-77493;DA-58144;FS108549;SP(1-11);NS00074307;G12247;RPKPQQFFGLM (modifications: C-terminal amide);Q411041;Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2;Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-amine;BRD-K23106423-001-01-0;(SP)Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2;H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-D-Phe-Gly-Leu-Met-NH2;Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2(substance P);Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2.(Substance P);H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 acetate salt;H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2(Substance P);Substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2);251-545-8;METHIONINAMIDE, L-ARGINYL-L-PROLYL-L-LYSYL-L-PROLYL-L-GLUTAMINYL-L-GLUTAMINYL-L-PHENYLALANYL-L-PHENYLALANYLGLYCYL-L-LEUCYL-;

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cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C63H98N18O13S
M.W/Mr.
1347.6
Sequence
One Letter Code:RPKPQQFFGLM
Three Letter Code:H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
Activity
Modulator
Biological Activity
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).
Target
Neurokinin Receptor
InChI
InChI=1S/C63H98N18O13S/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1
InChI Key
ADNPLDHMAVUMIW-CUZNLEPHSA-N

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