Substance P is a neuropeptide, acting as a neurotransmitter and as a neuromodulator.The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).
CAT No: R1691
CAS No:33507-63-0
Synonyms/Alias:Substance P;33507-63-0;Neurokinin P;Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2;CCRIS 7229;Substance P acetate salt;EINECS 251-545-8;Neuropeptide sp-1;Sh-oligopeptide-73;Substance p (1-11);675VGV5J1D;CHEMBL235363;12769-48-1;ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 3ACOH 5H2O;11035-08-8;C63H98N18O13S;UNII-675VGV5J1D;substance-P;Substanz-P;Neurokinin-1;Substance P?;Neurokinin P TFA;[3H]-substance P;Substance P (smooth-muscle stimulant);[125I]-substance P;137348-11-9;Euler Gaddum Substance P;Euler-Gaddum Substance P;SUBSTANCE P [MI];Substance P, Euler-Gaddum;tachykinin substance P (SP);GTPL2098;GTPL3805;GTPL3835;H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2;SCHEMBL1116347;[3H]SP (human, mouse, rat);SCHEMBL20844802;CHEBI:80308;[3H]-SP;ArgProLysProGlnGlnPhePheGlyLeuMet;[125I]SP (human, mouse, rat);SH-OLIGOPEPTIDE-73 [INCI];[125I]-SP;BDBM50001450;HB2915;AKOS024456424;FS73619;NCGC00167123-01;AS-77493;DA-58144;FS108549;SP(1-11);NS00074307;G12247;RPKPQQFFGLM (modifications: C-terminal amide);Q411041;Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met NH2;Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-amine;BRD-K23106423-001-01-0;(SP)Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2;H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-D-Phe-Gly-Leu-Met-NH2;Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2(substance P);Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2.(Substance P);H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 acetate salt;H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2(Substance P);Substance P (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2);251-545-8;METHIONINAMIDE, L-ARGINYL-L-PROLYL-L-LYSYL-L-PROLYL-L-GLUTAMINYL-L-GLUTAMINYL-L-PHENYLALANYL-L-PHENYLALANYLGLYCYL-L-LEUCYL-;
Substance P is a neuropeptide belonging to the tachykinin family, characterized by its pivotal role as a neurotransmitter and neuromodulator in both the central and peripheral nervous systems. Comprising eleven amino acids, it is widely recognized for mediating signal transduction related to pain perception, inflammatory processes, and various physiological responses. Its broad distribution in neural tissue, as well as peripheral organs, has established Substance P as a critical subject of investigation in neurobiology, pharmacology, and peptide signaling research. The compound's unique ability to interact with neurokinin-1 (NK1) receptors underpins its significance in studies of sensory transmission and neuroimmune communication, making it an invaluable tool for advancing our understanding of peptide-mediated biological functions.
Neurobiology research: Substance P is extensively utilized in neurobiological studies to elucidate the mechanisms underlying pain transmission, stress response, and mood regulation. By acting as a key ligand for NK1 receptors, it enables researchers to dissect the molecular pathways involved in nociceptive signaling and central sensitization. Application of this peptide in in vitro and in vivo models allows for detailed mapping of neural circuits implicated in pain processing and emotional regulation, facilitating the development of new hypotheses regarding neurotransmitter interactions and receptor dynamics.
Inflammation and immunomodulation studies: The peptide serves as an important molecular probe for investigating neurogenic inflammation and the interface between the nervous and immune systems. Its ability to stimulate cytokine release, modulate immune cell activity, and influence vascular permeability makes it a valuable tool in characterizing the cellular and molecular events driving inflammatory responses. Researchers deploy it in experimental models to unravel the contribution of neuropeptides to chronic inflammation, tissue injury, and immune cell recruitment, providing foundational insights for the broader field of neuroimmunology.
Receptor pharmacology: Substance P is a standard ligand in receptor binding assays and signal transduction studies focused on the neurokinin receptor family, particularly NK1. Its high affinity and specificity for these receptors enable precise characterization of receptor-ligand interactions, downstream signaling cascades, and receptor desensitization phenomena. Utilization of the peptide in pharmacological profiling supports the screening and validation of novel receptor antagonists or modulators, thus advancing the development of new research tools and experimental therapeutics targeting tachykinin pathways.
Peptide structure-function analysis: As a well-characterized neuropeptide, Substance P is frequently employed in structure-activity relationship (SAR) studies to investigate the impact of amino acid sequence modifications on biological activity and receptor affinity. Synthetic analogs and labeled derivatives are used in conjunction with the native peptide to probe the structural determinants of receptor binding and activation. These investigations inform peptide engineering strategies and support the rational design of new bioactive molecules for research applications.
Analytical method development: The compound is also instrumental in the calibration and validation of analytical techniques such as high-performance liquid chromatography (HPLC), mass spectrometry, and immunoassays. Its defined sequence and robust detectability make it a preferred reference standard for assessing assay sensitivity, specificity, and reproducibility in peptide quantification workflows. This role is particularly important in laboratories developing new methodologies for the detection and measurement of neuropeptides in complex biological samples.
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