Sulanemadlin is a synthetic compound featuring aromatic, polar, and hydrophobic regions that influence its conformational distribution. Researchers use it to probe ligand-protein interactions, modular binding motifs, and sterically driven orientation changes. Its scaffold supports structural and mechanistic exploration. The compound's balanced design aids broad biochemical analysis.
CAT No: R2277
CAS No:1451199-98-6
Synonyms/Alias:Sulanemadlin;Sulanemadlin [INN];6BGF28R54M;Sulanemadlin [USAN];ALRN-6924;UNII-6BGF28R54M;CHEMBL5394570;1451199-98-6;ALRN6924;N-Acetyl-L-leucyl-L-threonyl-L-phenylalanyl-cyclo(D-R8-L-glutamyl-ltyrosyl-ltryptophanyl-L-alanyl-L-glutaminyl-L-leucyl-L-S5)-L-alanyl-lalanyl-L-alanyl-L-alanyl-lalanyl-D-alanylamide;Sulanemadlin [USAN:INN];Alrn 6924;WHO 11411;Sulanemadlin (USAN/INN);ALRN 6924 [WHO-DD];GLXC-27604;HY-P4210;BDBM50624183;CS-0650265;D12399;C2.11,C2.4-[(4E)-undec-4-ene-1,11-diyl](N-acetyl-Lleucyl-L-threonyl-L-phenylalanyl-L-alanyl-L-alpha-glutamylL-tyrosyl-L-tryptophyl-L-alanyl-L-glutaminyl-L-leucyl-D-alanyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-D-alaninamide);D-Alaninamide, 42,112-(7E)-7-undecene-1,11-diyl-N-acetyl-L-leucyl-Lthreonyl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-L-tyrosyl-L-tryptophyl-L-alanyl-L-glutaminyl-L-leucyl-D-alanyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-;
Sulanemadlin is a small-molecule compound recognized for its potent and selective inhibition of the MDM2-p53 protein-protein interaction, a critical regulatory axis in cellular stress responses and tumor biology. As a synthetic inhibitor, sulanemadlin disrupts the binding of MDM2 to the tumor suppressor protein p53, thereby stabilizing and activating p53's transcriptional functions. This mechanism has positioned sulanemadlin as a valuable research tool for probing the intricacies of cell cycle regulation, apoptosis, and DNA damage response pathways. Its high specificity and well-characterized mode of action make it a preferred choice for researchers investigating p53-dependent signaling and related molecular mechanisms in both basic and translational settings.
Mechanistic studies: Sulanemadlin is widely utilized in in vitro and cell-based assays to investigate the molecular dynamics of the MDM2-p53 interaction. By competitively inhibiting MDM2, it allows for the functional reactivation of p53, enabling detailed studies of downstream gene expression, protein stability, and cellular outcomes following p53 activation. Such mechanistic insights are crucial for elucidating the role of p53 in cell fate decisions, genome integrity maintenance, and response to genotoxic stress.
Cancer biology research: The compound serves as a pivotal tool in oncology-focused laboratories for modeling the consequences of p53 pathway reactivation in tumor cells. Researchers employ sulanemadlin to simulate pharmacological restoration of p53 function in various cancer cell lines, facilitating the analysis of cell proliferation, senescence, and apoptotic responses. These studies provide a foundation for understanding tumor suppressor pathways and the molecular vulnerabilities of malignancies with intact or dysfunctional p53 signaling.
Drug discovery and screening: Sulanemadlin is frequently integrated into high-throughput screening platforms and structure-activity relationship (SAR) studies targeting the p53-MDM2 axis. Its robust activity profile and well-defined target enable its use as a reference inhibitor or positive control in the evaluation of novel small molecules or peptide mimetics. This approach accelerates the identification and optimization of new chemical entities with potential as modulators of protein-protein interactions relevant to cancer and cellular stress responses.
Cellular stress modeling: The compound is instrumental in experimental systems designed to mimic cellular responses to DNA damage or oncogenic stress. By stabilizing p53, sulanemadlin facilitates the dissection of stress-induced signaling networks, autophagy, and metabolic adaptation in cultured cells. Its use in these contexts enhances the understanding of how cells orchestrate survival or death decisions under adverse conditions, informing broader research on cell biology and pathophysiology.
Pathway validation and biomarker studies: In addition to mechanistic and screening applications, sulanemadlin is employed to validate the functional relevance of the p53 pathway in preclinical models. Researchers utilize it to modulate p53 activity and assess the expression of p53-responsive genes, proteins, and biomarkers. These investigations support the identification of molecular signatures associated with p53 pathway modulation, offering valuable data for translational research and the development of pathway-specific diagnostic tools.
Collectively, sulanemadlin's well-characterized inhibition of the MDM2-p53 interaction underpins its broad utility in molecular biology, cancer research, and chemical biology applications. Its role in dissecting p53-dependent mechanisms, validating therapeutic targets, and supporting the discovery of novel modulators makes it an indispensable reagent for advanced scientific investigations into cellular regulation and disease processes.
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