Tertiapin Q is a stable derivative of the bee venom toxin tertiapin. It is a high affinity blocker for inward-rectifier K+ channels that binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels with high affinity (Ki values are 1.3 and 13.3 nM respectively).
CAT# | R1101 |
CAS | 910044-56-3 |
Synonyms/Alias | TPNQ, Tertiapin (M13Q), (Gln¹³)-Tertiapin |
M.F/Formula | C106H175N35O24S4 |
M.W/Mr. | 2452 |
Sequence | ALCNCNRIIIPHQCWKKCGKK(Disulfide bridge between Cys3 and Cys14, Cys5 and Cys18, Lys-21 = C-terminal amide) |
Labeling Target | Potassium channel |
Appearance | White lyophilised solid |
Activity | Blocker |
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