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trans-4-Hydroxy-D-proline

trans-4-Hydroxy-D-proline is a non-proteinogenic proline derivative featuring a five-membered pyrrolidine ring with a hydroxyl substituent at the 4-position and a trans relationship between the ring and side-chain stereochemical elements, specified here with D stereochemistry at the proline carbon. The molecule contains both an amino group and a carboxyl group, and the 4-hydroxyl side-chain provides hydrogen-bonding and polarity that can influence conformational preferences in peptide backbones where it is incorporated. trans-4-Hydroxy-D-proline is used in peptide chemistry and structure-property studies to introduce a hydroxyl-bearing, stereodefined proline motif for preparing modified peptides, conformational probes, and related amino acid building blocks for chemical biology workflows.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: CP01102

CAS No:3398-22-9

Synonyms/Alias:trans-4-Hydroxy-D-proline;3398-22-9;(2R,4S)-4-hydroxypyrrolidine-2-carboxylicacid;D-Proline,4-hydroxy-,(4S)-;(2R,4S)-4-Hydroxy-pyrrolidine-2-carboxylicacid;H-D-Hyp-OH;3348-22-9;AmbotzHAA1169;PubChem9966;4alpha-Hydroxy-D-proline;AC1L98MJ;trans-4-Hydroxy-DL-proline;(4S)-4-hydroxy-D-proline;SCHEMBL200243;CTK4H1557;MolPort-001-770-652;PMMYEEVYMWASQN-IUYQGCFVSA-N;ZINC895457;ANW-27751;MFCD00065608;AKOS006349670;AKOS015855303;RP19947;AJ-24189;AK-41934

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M.F/Formula
C5H9NO3
M.W/Mr.
131.13
Abbr
H-D-Hyp-OH
InChI
1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m0/s1
InChI Key
PMMYEEVYMWASQN-IUYQGCFVSA-N
Canonical SMILES
C1C(CNC1C(=O)O)O

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