Transportan is a 27 amino acid-long peptide containing 12 functional amino acids from the amino terminus of the neuropeptide galanin and mastoparan in the carboxyl terminus, connected via a lysine. Transportan belongs to cell-penetrating peptides (CPPs).
CAT No: R1729
CAS No:203716-10-3
Synonyms/Alias:Transportan;203716-10-3;DA-58703;NH2-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Lys-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2;
Transportan is a synthetic chimeric peptide renowned for its cell-penetrating capabilities, combining structural motifs from the neuropeptide galanin and the wasp venom peptide mastoparan. As a member of the cell-penetrating peptide (CPP) family, Transportan possesses a unique sequence that facilitates efficient translocation across biological membranes. Its amphipathic and cationic nature enables it to interact favorably with lipid bilayers, allowing for the non-endocytic internalization of various molecular cargos. This distinctive property has positioned Transportan as a valuable tool in biochemical research, particularly in studies focused on intracellular delivery, molecular transport mechanisms, and peptide-membrane interactions.
Intracellular Delivery Studies: Utilization of Transportan in research enables the efficient delivery of bioactive molecules, including peptides, proteins, nucleic acids, and small organic compounds, into living cells. Its ability to traverse cellular membranes without significant cytotoxicity or membrane disruption makes it an ideal vehicle for probing intracellular signaling pathways, gene expression, and protein function. Researchers leverage this peptide to overcome the permeability barrier that typically limits the intracellular access of large or hydrophilic molecules, thereby expanding the experimental possibilities in cellular and molecular biology.
Peptide-Membrane Interaction Analysis: The structural features of Transportan provide a robust model for investigating the mechanisms by which amphipathic peptides interact with lipid bilayers. Studies employing this peptide have elucidated the role of charge distribution, hydrophobicity, and secondary structure in membrane association and penetration. Such investigations contribute to a deeper understanding of membrane dynamics, peptide-lipid interactions, and the biophysical principles underlying cellular uptake processes. These insights are instrumental in the rational design of novel CPPs and membrane-active agents.
Cargo Conjugation and Delivery System Development: Researchers frequently use Transportan as a foundational scaffold for the development of advanced delivery systems. By covalently linking it to various cargos or modifying its sequence, scientists can tailor its transport properties to specific experimental needs. This approach supports the creation of targeted delivery platforms for in vitro applications, facilitating the precise manipulation of cellular environments and enabling functional studies that require controlled intracellular localization of research compounds.
Fluorescent and Imaging Probe Delivery: The peptide's capacity to ferry fluorescent dyes and imaging probes across cell membranes is exploited in live-cell imaging and subcellular localization studies. By conjugating Transportan to fluorophores or reporter molecules, researchers can achieve rapid and efficient labeling of intracellular structures, allowing for real-time visualization of dynamic cellular processes. This application is particularly valuable in high-content screening, confocal microscopy, and studies requiring spatial and temporal resolution of molecular events within living cells.
Structure-Activity Relationship (SAR) Research: The modular architecture of Transportan makes it a prime candidate for systematic structure-activity relationship investigations. By introducing targeted amino acid substitutions or sequence modifications, scientists can dissect the contributions of specific residues to cellular uptake efficiency, cargo compatibility, and membrane interaction profiles. These SAR studies not only enhance fundamental knowledge of CPP function but also inform the design of next-generation peptides with optimized delivery characteristics for diverse biochemical research applications.
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