Urofollitropin is a recombinant hormone used in assisted reproductive technology to support ovarian follicle development for controlled ovarian stimulation. It acts as a follicle-stimulating hormone (FSH) analog.
CAT No: R1999
CAS No:97048-13-0
Chemical Name:1-[19-amino-7-(2-amino-2-oxoethyl)-13-butan-2-yl-10-(1-hydroxyethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
Urofollitropin is a highly purified form of human follicle-stimulating hormone (FSH), classified as a glycoprotein hormone derived from urinary sources. As a member of the gonadotropin family, urofollitropin plays a pivotal role in the regulation of reproductive physiology, particularly in the stimulation of follicular development within the ovaries. Its biochemical activity is characterized by the ability to bind and activate the FSH receptor, thereby modulating key intracellular signaling pathways associated with gametogenesis. The compound's structural and functional fidelity to endogenous FSH makes it a valuable tool for research applications focused on reproductive endocrinology, cellular signaling, and hormone-receptor interactions.
Endocrine research: Urofollitropin is widely employed in studies investigating the molecular mechanisms underlying pituitary-gonadal axis regulation. Its defined activity profile enables researchers to dissect the specific contributions of FSH to ovarian folliculogenesis and spermatogenesis in vitro and in animal models. By providing a reliable exogenous source of biologically active FSH, it facilitates controlled experiments on granulosa cell proliferation, differentiation, and the expression of steroidogenic enzymes, thereby advancing the understanding of reproductive hormone signaling networks.
Cell signaling studies: Due to its capacity to selectively activate the FSH receptor, urofollitropin serves as an essential reagent for elucidating downstream signaling cascades in target cells. Researchers utilize it to probe cyclic AMP (cAMP) production, protein kinase A (PKA) activation, and gene expression patterns associated with FSH receptor engagement. Such studies provide critical insights into receptor pharmacology, signal transduction specificity, and the cross-talk between gonadotropin-mediated pathways and other hormonal or growth factor signals.
Reproductive toxicology: Urofollitropin is instrumental in toxicological assessments that examine the impact of environmental agents, pharmaceuticals, or novel compounds on reproductive function. By serving as a standardized stimulant for ovarian or testicular tissue in ex vivo and in vivo models, it allows for the evaluation of toxicant-induced alterations in follicular development, hormone responsiveness, and gamete maturation. These applications contribute to the identification of endocrine-disrupting chemicals and support the safety profiling of new drug candidates.
Assay development: The purified nature of urofollitropin makes it an ideal reference material for the development and calibration of immunoassays or bioassays targeting FSH activity. Its consistent potency and biochemical characteristics enable the establishment of robust assay systems for quantifying FSH levels in biological samples, screening for receptor agonists or antagonists, and validating the specificity and sensitivity of analytical platforms. Such assays are indispensable in both basic research and biopharmaceutical quality control.
Bioprocessing and biotechnology: In the context of cell culture and bioprocess optimization, urofollitropin is utilized to support the growth and differentiation of specialized cell lines, particularly those derived from reproductive tissues. Its addition to defined media formulations can enhance the physiological relevance of in vitro models, promoting more accurate recapitulation of ovarian or testicular microenvironments. This approach is valuable for applications ranging from gamete maturation protocols to the production of recombinant proteins in gonadotropin-responsive systems.
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