Vasonatrin Peptide (VNP) Trifluoroacetate contains a structured sequence balancing polar, charged, and hydrophobic residues that shape receptor-binding characteristics. The trifluoroacetate counterion improves solubility and handling. Researchers explore its folding behavior and dynamic transitions in aqueous media. Applications include signaling-motif analysis, structural modeling, and peptide engineering.
CAT No: R2656
CAS No:141676-35-9
Synonyms/Alias:Vasonatrin Peptide (VNP) Trifluoroacetate;141676-35-9;FV108689;Vasonatrin Peptide (VNP) trifluoroacetate salt;H-Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly -Cys-Asn-Ser-Phe-Arg-Tyr-OH; H-GLSKGCFGLKLDRIG SMSGLGCNSFRY-OH;
Vasonatrin Peptide (VNP) Trifluoroacetate is a synthetic peptide compound that combines the structural motifs of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP), resulting in a chimeric molecule with unique biological properties. As a member of the natriuretic peptide family, VNP is characterized by its ability to interact with natriuretic peptide receptors, thereby influencing key physiological processes such as vasodilation, natriuresis, and diuresis in experimental systems. Its structural design and functional attributes make it highly relevant for research focused on cardiovascular physiology, renal function, and peptide-receptor interactions. The trifluoroacetate salt form ensures stability and compatibility with standard biochemical workflows, supporting its integration into a wide range of peptide research applications.
Peptide-receptor interaction studies: VNP is widely utilized in research investigating the molecular mechanisms of natriuretic peptide receptor activation and signaling. By serving as a tool to probe the binding affinities, selectivity, and downstream effects on guanylyl cyclase-coupled receptors, it enables detailed analysis of receptor subtype specificity and structure-activity relationships. Such studies are essential for elucidating the distinct signaling cascades initiated by different natriuretic peptides and for advancing the understanding of receptor-ligand interactions in cardiovascular and renal models.
Vascular biology research: The peptide's unique chimeric structure, which imparts both ANP-like and CNP-like properties, makes it an important agent in the study of vascular tone regulation and endothelial function. Researchers leverage VNP to explore its effects on vasorelaxation, endothelial nitric oxide production, and smooth muscle cell responses in isolated vessel assays or tissue culture systems. These investigations contribute valuable insights into the modulation of vascular homeostasis and the molecular underpinnings of blood pressure regulation.
Renal physiology experiments: VNP is frequently applied in experimental models to examine its influence on renal hemodynamics, sodium excretion, and water balance. By comparing its natriuretic and diuretic effects to those of naturally occurring peptides, scientists can dissect the contributions of structural modifications to renal signaling pathways. Such approaches are instrumental in mapping the physiological roles of natriuretic peptides and in characterizing their impact on kidney function under various experimental conditions.
Peptide structure-function analysis: The chimeric nature of VNP provides a valuable framework for investigating the relationship between peptide sequence, three-dimensional conformation, and biological activity. Researchers employ this compound in structure-activity relationship (SAR) studies, using techniques such as site-directed mutagenesis, peptide mapping, and biophysical characterization to delineate critical residues and motifs responsible for receptor engagement and functional specificity. These efforts inform rational peptide design and the development of novel analogs with tailored biological profiles.
Peptide synthesis and analytical method development: VNP serves as a reference standard and validation tool in the optimization of solid-phase peptide synthesis (SPPS) protocols and analytical techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry. Its defined sequence and physicochemical properties facilitate method calibration, purity assessment, and the benchmarking of synthetic efficiency. This application is particularly valuable for quality control processes and for advancing peptide manufacturing technologies within research and industrial settings.
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