Vipivotide tetraxetan Linker is a modular peptide spacer engineered to support conjugation with tetraxetan chelators or targeting motifs. Its sequence balances flexibility with controlled steric bulk to maintain structural accessibility. Researchers evaluate its coordination compatibility and conformational adaptability. Applications include radioligand construction, peptide-chelator engineering, and linker-optimization studies.
CAT No: R2317
CAS No:1703768-74-4
Synonyms/Alias:Vipivotide tetraxetan Linker;1703768-74-4;PSMA-617 Linker;(2S)-2-[[(1S)-5-[[(2S)-2-[[4-(aminomethyl)cyclohexanecarbonyl]amino]-3-naphthalen-2-ylpropanoyl]amino]-1-carboxypentyl]carbamoylamino]pentanedioic acid;JUN68744;PSMA-617 Linker?;(2S)-2-({[(1S)-1-carboxy-5-[(2S)-3-(naphthalen-2-yl)-2-{[(1r,4r)-4-(aminomethyl)cyclohexyl]formamido}propanamido]pentyl]carbamoyl}amino)pentanedioic acid;EX-A9930;AKOS040742816;DA-68599;HY-43869;CS-0095890;F82404;
Vipivotide tetraxetan Linker is a specialized carbohydrate-based compound designed to facilitate the conjugation of biomolecules, particularly in the field of targeted drug delivery and molecular imaging. Distinguished by its unique structural features, this linker incorporates multiple functional groups that enable efficient attachment to both payloads and targeting moieties. Its design leverages the inherent stability and hydrophilicity of carbohydrate scaffolds, which can enhance solubility and biocompatibility in complex biological environments. As a result, this linker is increasingly recognized for its versatility in enabling precise molecular assembly, expanding the toolkit available to researchers developing advanced bioconjugates.
Antibody-Drug Conjugate Development: Vipivotide tetraxetan Linker plays a pivotal role in the construction of antibody-drug conjugates (ADCs), serving as a bridge between monoclonal antibodies and cytotoxic agents. By offering a stable yet cleavable connection, the linker ensures that the therapeutic payload remains securely attached during systemic circulation, only releasing the drug upon reaching the targeted cellular environment. This selective release mechanism is critical for maximizing therapeutic efficacy while minimizing off-target effects, making it a valuable component in the rational design of next-generation ADCs.
Radiopharmaceutical Synthesis: In the realm of molecular imaging and targeted radiotherapy, the tetraxetan linker is frequently employed to chelate radiometals and attach them to targeting ligands such as peptides or antibodies. Its robust chelating properties, derived from the macrocyclic structure, facilitate the stable incorporation of radionuclides, thereby improving the pharmacokinetics and imaging resolution of radiolabeled probes. The use of this linker in radiopharmaceuticals supports the development of highly specific imaging agents for non-invasive diagnostics and research applications.
Peptide Conjugation: The carbohydrate-based structure of Vipivotide tetraxetan Linker makes it an excellent choice for peptide conjugation, allowing for the attachment of various functional groups or reporter molecules. Its hydrophilic nature aids in maintaining peptide solubility and bioavailability, while the multiple reactive sites provide flexibility in conjugation strategies. Researchers utilize this linker to create multifunctional peptide conjugates for use in bioanalytical assays, targeted delivery systems, and mechanistic studies, thus expanding the scope of peptide-based research.
Nanoparticle Surface Modification: The unique chemical attributes of the tetraxetan linker enable its use in nanoparticle surface modification, where it acts as an intermediary for attaching targeting ligands, drugs, or imaging agents to nanocarrier surfaces. By improving the stability and functionality of these nanoconstructs, the linker enhances their performance in drug delivery and imaging applications. Its compatibility with a variety of nanoparticle materials, including liposomes and polymeric nanoparticles, underscores its adaptability within the rapidly evolving field of nanomedicine.
Biomolecular Assembly and Engineering: Vipivotide tetraxetan Linker is increasingly leveraged in the assembly of complex biomolecular constructs, such as multivalent ligands and synthetic scaffolds. Its ability to provide spatial control over the orientation and spacing of attached molecules is particularly valuable in the engineering of multifunctional platforms for biochemical assays, biosensors, and molecular diagnostics. By enabling precise and customizable molecular architectures, this linker supports innovative approaches to studying and manipulating biological systems at the molecular level, thereby advancing both fundamental research and applied biotechnology.
2. Immune responses to homocitrulline-and citrulline-containing peptides in rheumatoid arthritis
5. Cell-based adhesion assays for isolation of snake venom’s integrin antagonists
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