Y1 receptor antagonist 1 serves as a functional peptide-derived molecule for analyzing receptor-ligand determinants in neurochemical pathways. Its architecture supports evaluations of steric effects and charge distribution in binding pockets. Researchers employ it to dissect molecular interactions governing receptor modulation. Broad relevance spans biochemical pharmacology models, ligand design, and structural optimization.
CAT No: R2618
CAS No:221697-09-2
Synonyms/Alias:Y1 receptor antagonist 1;221697-09-2;H-409/22;Ar-H040922 freebase;7NCK567YKQ;(2R)-5-(diaminomethylideneamino)-2-[(2,2-diphenylacetyl)amino]-N-[(1R)-1-(4-hydroxyphenyl)ethyl]pentanamide;(2R)-2-((2,2-Diphenylacetyl)amino)-5-guanidino-N-((1R)-1-(4-hydroxyphenyl)ethyl)pentanamide;UNII-7NCK567YKQ;H 409-22;SCHEMBL1593464;AKOS040733811;CS-7270;DA-68753;MS-29063;HY-101704;BENZENEACETAMIDE, N-((1R)-4-((AMINOIMINOMETHYL)AMINO)-1-((((1R)-1-(4-HYDROXYPHENYL)ETHYL)AMINO)CARBONYL)BUTYL)-.ALPHA.-PHENYL-;Benzeneacetamide, N-((1R)-4-((aminoiminomethyl)amino)-1-((((1R)-1-(4-hydroxyphenyl)ethyl)amino)carbonyl)butyl)-alpha-phenyl-;N-((1R)-4-((AMINOIMINOMETHYL)AMINO)-1-((((1R)-1-(4-HYDROXYPHENYL)ETHYL)AMINO)CARBONYL)BUTYL)-.ALPHA.-PHENYLBENZENEACETAMIDE;N-((1R)-4-((Aminoiminomethyl)amino)-1-((((1R)-1-(4-hydroxyphenyl)ethyl)amino)carbonyl)butyl)-alpha-phenylbenzeneacetamide;
Y1 receptor antagonist 1 is a specialized carbohydrate compound designed to selectively inhibit the activity of the neuropeptide Y1 receptor, a G protein-coupled receptor implicated in diverse physiological processes. Characterized by its targeted mechanism of action, Y1 receptor antagonist 1 provides researchers with a valuable tool for dissecting the functional roles of neuropeptide Y (NPY) signaling pathways in a variety of experimental models. Its robust binding affinity and specificity make it a preferred choice in studies requiring precise modulation of receptor activity without interfering with other receptor subtypes. The compound's stability and solubility further enhance its utility in a wide range of in vitro and in vivo research settings, supporting the advancement of neurobiological and metabolic investigations.
Neuroscience Research: In neuroscience, Y1 receptor antagonist 1 is widely utilized to delineate the contributions of NPY and its receptor in central nervous system functions. By selectively blocking Y1 receptor-mediated signaling, scientists can investigate its role in processes such as synaptic transmission, neuroplasticity, and neural circuit modulation. This targeted inhibition allows for the exploration of how NPY influences behaviors related to anxiety, mood, and stress response. The antagonist serves as a critical tool for mapping receptor distribution, characterizing downstream signaling events, and evaluating the physiological relevance of Y1 receptor activation in neural pathways.
Metabolic Regulation Studies: In metabolic research, Y1 receptor antagonists are instrumental in unraveling the regulatory networks that govern appetite, energy homeostasis, and adiposity. Through the selective inhibition of Y1 receptor activity, researchers can assess the impact of NPY signaling on food intake, energy expenditure, and lipid metabolism. These studies provide valuable insights into the molecular mechanisms underpinning metabolic disorders such as obesity and metabolic syndrome. The ability to modulate receptor function with precision enables the identification of potential targets for therapeutic intervention and the development of novel strategies for metabolic health management.
Cardiovascular Function Analysis: The investigation of cardiovascular physiology benefits significantly from the application of Y1 receptor antagonist 1. NPY and its receptors are known to influence vascular tone, blood pressure regulation, and cardiac function. By employing this compound, researchers can dissect the specific contributions of Y1 receptor signaling to vasoconstriction, endothelial function, and myocardial contractility. Experimental models utilizing the antagonist help clarify the interplay between neuropeptide signaling and cardiovascular homeostasis, offering a deeper understanding of the molecular basis of vascular disorders and potential avenues for pharmacological modulation.
Pain and Nociception Research: Y1 receptor antagonist 1 is also a valuable asset in the study of pain mechanisms and nociceptive processing. NPY has been implicated in the modulation of pain perception at both the central and peripheral levels. By blocking Y1 receptor activity, scientists can investigate the receptor's role in pain signaling pathways, assess alterations in pain threshold, and explore its involvement in chronic pain states. These investigations contribute to the identification of novel targets for analgesic development and enhance our understanding of the neurochemical basis of pain modulation.
Behavioral Pharmacology: In the field of behavioral pharmacology, the compound is employed to examine the influence of NPY-Y1 receptor interactions on a spectrum of behaviors, including feeding, anxiety, locomotion, and reward. By selectively antagonizing the Y1 receptor, researchers can parse out the behavioral effects mediated through this receptor subtype and differentiate them from those involving other NPY receptors. Such studies are essential for elucidating the neurobiological underpinnings of complex behaviors and for identifying potential targets for behavioral intervention strategies. Through these diverse application directions, Y1 receptor antagonist 1 continues to facilitate groundbreaking research across multiple scientific disciplines, driving forward our understanding of neuropeptide signaling and its far-reaching physiological impacts.
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