Z-Asp(OSu)-OMe is an activated, protected aspartic acid derivative bearing a side-chain N-hydroxysuccinimide (OSu) ester and a methyl ester (OMe) at the carboxyl group, with the α-amino functionality protected as a benzyloxycarbonyl (Z/Cbz-type) carbamate. The molecule contains both a carbamate-protected amine and an OSu-activated carboxylate equivalent on the side chain, which provides a leaving group for acyl transfer chemistry while the esterification modulates overall polarity and reactivity. Z-Asp(OSu)-OMe is used in peptide and bioconjugation-oriented synthesis as an amino acid building block or coupling intermediate, where the OSu ester can serve as a functional handle for forming amide linkages under conditions compatible with the Z-protected amino group.
1. Cationic cell-penetrating peptides are potent furin inhibitors
2. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function
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