Z-D-Asn(Mtt)-OH is a protected, stereochemically defined amino acid derivative featuring an asparagine side chain bearing an Mtt (methyltrityl) group on the side-chain amide nitrogen, with the alpha-amino functionality protected as a Z (benzyloxycarbonyl, Cbz-type) carbamate and the carboxyl group present as a free acid. The molecule contains both a carboxylic acid and carbamate-protected amine functionality, while the Mtt substituent provides steric shielding and acid-labile deprotection behavior for the side-chain amide during stepwise assembly of peptide frameworks. Z-D-Asn(Mtt)-OH is used as a building block in peptide synthesis and chemical biology workflows where controlled deprotection of the side-chain amide is required to access Asn-like functionality for further coupling, conjugation, or structural studies.
1. Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes
2. An Open-label, Single-center, Safety and Efficacy Study of Eyelash Polygrowth Factor Serum
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