Z-D-aspartic acid β-tert.butyl ester monohydrate

Z-D-aspartic acid β-tert.butyl ester monohydrate is a protected, D-configured aspartic acid derivative in which the α-amino group is protected as a benzyloxycarbonyl (Z/Cbz) carbamate and the side-chain carboxyl is esterified as a β-tert-butyl ester. The molecule contains a free esterified carboxyl functionality masked by the tert-butyl group, a carbamate-linked nitrogen, and a carboxyl/ester carbonyl environment consistent with aspartate chemistry, with the "monohydrate" indicating one associated water molecule in the solid form. It is used as a stepwise peptide-synthesis building block or as a protected aspartate intermediate for preparing aspartyl-containing peptides and related amide derivatives while maintaining chemoselectivity between the α-amino and β-carboxyl functionalities.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: CP00436

CAS No:71449-08-6

Synonyms/Alias:71449-08-6;z-d-asp(otbu)-ohh2o;210471-09-3;Z-D-Asp(OtBu)-OHhydrate;(R)-2-(((Benzyloxy)carbonyl)amino)-4-(tert-butoxy)-4-oxobutanoicacidhydrate;Cbz-D-asparticacid4-tert-butylesterhydrate;Z-D-Asp(OtBu)-OH.H2O;C16H21NO6.H2O;Z-D-Asp(OtBu)-OHinvertedexclamationmarkcurrencyH2O;Z-D-Asp(OtBu)-OH2O;Z-D-ASP-OHH2O;SCHEMBL2580712;MolPort-002-499-117;CZ-102;AKOS015950958;AK164980;AN-37640;AB1006974;FT-0689539;ST24050362;V4305;X5767;z-d-asparticacid-beta-tertbutylesterh2o;B-7831;A837183

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Drug master files (DMF) filing

M.F/Formula

C16H23NO7

M.W/Mr.

341.3

Abbr

Z-D-Asp(OtBu)-OH.H2O

InChI

1S/C16H21NO6.H2O/c1-16(2,3)23-13(18)9-12(14(19)20)17-15(21)22-10-11-7-5-4-6-8-11;/h4-8,12H,9-10H2,1-3H3,(H,17,21)(H,19,20);1H2/t12-;/m1./s1

InChI Key

UWDOQNWFLPMMLQ-UTONKHPSSA-N

Canonical SMILES

CC(C)(C)OC(=O)CC(C(=O)O)NC(=O)OCC1=CC=CC=C1.O

1. Constitutive and inflammation-dependent antimicrobial peptides produced by epithelium are differentially processed and inactivated by the commensal Finegoldia magna and the pathogen Streptococcus pyogenes

2. The effect of B-type allatostatin neuropeptides on crosstalk between the insect immune response and cold tolerance

3. Urinary Metabolites Associated with Blood Pressure on a Low-or High-Sodium Die

4. Effect of Short-Term Desiccation, Recovery Time, and CAPA-PVK Neuropeptide on the Immune System of the Burying Beetle Nicrophorus vespilloides

5. Adipose tissue is a key organ for the beneficial effects of GLP-2 metabolic function

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