Z-D-Gla(OtBu)2-OH is a protected amino acid derivative of D-glutamic acid bearing a benzyloxycarbonyl (Z/Cbz) protecting group on the amino functionality and two tert-butyl ester protecting groups on the side-chain carboxylate, with a free carboxylic acid at the α-position. The molecule therefore contains a Z-protected α-amino group and three carboxyl-derived functionalities overall, where the side-chain carboxyls are masked as tert-butyl esters to control chemoselectivity during peptide coupling and to reduce undesired side reactions. In peptide chemistry and related synthetic studies, it functions as a stepwise building block that provides a protected glutamate side chain for incorporation into peptide intermediates and for preparing more complex glutamate-containing derivatives under conditions that tolerate the Z and tert-butyl ester protecting groups.
CAT No: CP25934
CAS No:60868-52-4
Chemical Name:N-alpha-(Benzyloxycarbonyl)-gamma-Carboxy-D-glutamic-acid-gamma-di-t-butyl ester
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