Z-D-glutamic acid

Z-D-glutamic acid is a protected amino acid derivative of D-glutamic acid, featuring the glutamate side chain with a terminal carboxylic acid and bearing a Z (benzyloxycarbonyl) protecting group on the amino functionality. The molecule contains both an unprotected carboxyl group on the side chain and a free carboxyl group at the α-position, while the α-amino group is masked by the Z carbamate to control chemoselectivity during peptide coupling. In synthetic peptide chemistry and amino acid derivatization workflows, it is employed as a stepwise building block to introduce a glutamate residue with the side-chain carboxyl group available for subsequent activation, protection, or conjugation strategies.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: CP00740

CAS No:63648-73-7

Synonyms/Alias:63594-37-6;H-ORN-OBZLHCL;H-Orn(Z)-OBzl.HCl;H-ORN(Z)-OBZLHCL;MolPort-020-004-765;KM0762;AKOS015910044;FT-0698731;I14-31135

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Registration of APIs
CMC information required for an IND

IND and NDA support
Drug master files (DMF) filing

M.F/Formula

C20H25ClN2O4

M.W/Mr.

281.3

Abbr

Z-D-Glu-OH

InChI

1S/C20H24N2O4.ClH/c21-18(19(23)25-14-16-8-3-1-4-9-16)12-7-13-22-20(24)26-15-17-10-5-2-6-11-17;/h1-6,8-11,18H,7,12-15,21H2,(H,22,24);1H/t18-;/m0./s1

InChI Key

XOTAHZAMYKJUFV-FERBBOLQSA-N

Canonical SMILES

C1=CC=C(C=C1)COC(=O)C(CCCNC(=O)OCC2=CC=CC=C2)N.Cl

1. An Open-label, Single-center, Safety and Efficacy Study of Eyelash Polygrowth Factor Serum

2. Novel Peptide-Based PD1 Immunomodulators Demonstrate Efficacy in Infectious Disease Vaccines and Therapeutics

3. Investigating Potential Interactions Between Neurohypophyseal Peptides, their Drug Analogs, and Coagulation Factor VIII

4. Myotropic activity of allatostatins in tenebrionid beetles

5. Proinsulin C-peptide and insulin: Limited pattern similarities of interest in inter-peptide interactions but no C-peptide effect on insulin and IGF-1 receptor signaling

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