Z-D-Val-OSu is a protected, derivatized amino acid derivative based on D-valine, bearing a benzyloxycarbonyl (Z, Cbz) protecting group on the amino functionality and an activated N-hydroxysuccinimide (OSu) ester at the carboxyl terminus. The molecule contains a free hydroxyl on the OSu moiety that forms the ester linkage to the amino acid carboxyl group, while the D-stereochemical configuration is retained from the D-valine backbone and the valine side chain features an isopropyl group with hydrophobic character. Z-D-Val-OSu is used as an acylating intermediate in peptide coupling and amide bond formation workflows, including preparation of peptide-related intermediates and labeling or conjugation strategies where a succinimidyl ester provides a controlled electrophilic handle for nucleophilic attack by amines.
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