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Z-Glu(OtBu)-OH

Z-Glu(OtBu)-OH is a protected glutamic acid derivative featuring a side-chain carboxylic acid masked as a tert-butyl ester (OtBu) and an α-amino group protected with a benzyloxycarbonyl (Z, Cbz) carbamate. The molecule contains a free carboxylic acid at the α-position (-COOH) while the protected side-chain carboxyl group is present as an ester, and the Z group provides chemoselectivity by suppressing amino reactivity under peptide-coupling conditions. Z-Glu(OtBu)-OH is used as a stepwise amino acid building block for peptide synthesis and for preparing glutamate-containing peptide or peptidomimetic intermediates where orthogonal deprotection can reveal the side-chain carboxyl functionality for subsequent coupling or conjugation.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: CP27076

CAS No:3886/8/6

Synonyms/Alias:Z-Glu(OtBu)-OH;3886-08-6;Cbz-Glu(OBut)-OH;(S)-2-(((Benzyloxy)carbonyl)amino)-5-(tert-butoxy)-5-oxopentanoicacid;SBB065851;Z-L-glutamicacid5-tert-butylester;l-glutamicacid,n-[(phenylmethoxy)carbonyl]-,5-(1,1-dimethylethyl)ester;N-Cbz-L-glutamicacidgamma-t-butylester;N-Cbz-L-glutamicAcid5-tert-ButylEster;(2S)-4-[(tert-butyl)oxycarbonyl]-2-[(phenylmethoxy)carbonylamino]butanoicacid;5-tert-ButylN-Carbobenzoxy-L-glutamate;EINECS223-421-3;PubChem6261;AC1Q5XL9;SCHEMBL42877;96129_ALDRICH;AC1L327G;96129_FLUKA;CTK7G2379;5-tert-ButylN-Cbz-L-glutamate;Z-Glutamicacidtert-butylester;GLMODRZPPBZPPB-ZDUSSCGKSA-N;MolPort-003-939-934;ZINC2390941;AR-1J3166

Chemical Name:N-alpha-Benzyloxycarbonyl-L-glutamic acid gamma-t-butyl ester

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M.F/Formula
C17H23NO6
M.W/Mr.
337.37
Size
5 g;25 g;100 g;
Abbr
Z-Glu(OtBu)-OH
InChI
1S/C17H23NO6/c1-17(2,3)24-14(19)10-9-13(15(20)21)18-16(22)23-11-12-7-5-4-6-8-12/h4-8,13H,9-11H2,1-3H3,(H,18,22)(H,20,21)/t13-/m0/s1
InChI Key
GLMODRZPPBZPPB-ZDUSSCGKSA-N
Canonical SMILES
CC(C)(C)OC(=O)CCC(C(=O)O)NC(=O)OCC1=CC=CC=C1

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