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Z-Glu(OtBu)-ONp

Z-Glu(OtBu)-ONp is a protected glutamic acid derivative in which the α-amino group is carbobenzyloxy-protected (Z/Cbz) and the side-chain γ-carboxyl is tert-butyl ester-protected, yielding a molecule bearing a masked amino acid framework suitable for peptide chemistry. The carboxyl functionality is present as an ONp ester (p-nitrophenyl ester), and the compound therefore contains an activated carboxyl group alongside the protected amine and protected side-chain carboxyl, with stereochemistry consistent with the glutamate scaffold as supplied by the product identity. Z-Glu(OtBu)-ONp is used as an amino-acid building block or activated intermediate for acylation steps in peptide synthesis and related conjugation workflows, where the ONp ester can serve as a leaving-group-bearing acyl donor while the Z and OtBu groups help control chemoselectivity during sequential assembly of more complex peptide derivatives.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: CP27445

CAS No:7670/8/8

Synonyms/Alias:Z-GLU(OTBU)-ONP;7670-08-8;AmbotzZAA1221;Cbz-Glu(OBut)-ONp;MolPort-003-983-024;ZINC71788218;AKOS015841367;KB-117994;N-[(Benzyloxy)carbonyl]-L-glutamicacid5-(1,1-dimethylethyl)1-(4-nitrophenyl)ester

Chemical Name:N-alpha-Benzyloxycarbonyl-L-glutamic acid alpha-(p-nitrophenyl) gamma-t-butyl ester

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M.F/Formula
C23H26N2O8
M.W/Mr.
458.47
Size
1 g;5 g;25 g;
InChI
1S/C23H26N2O8/c1-23(2,3)33-20(26)14-13-19(24-22(28)31-15-16-7-5-4-6-8-16)21(27)32-18-11-9-17(10-12-18)25(29)30/h4-12,19H,13-15H2,1-3H3,(H,24,28)/t19-/m0/s1
InChI Key
QELUBUSZCPJCNC-IBGZPJMESA-N
Canonical SMILES
CC(C)(C)OC(=O)CCC(C(=O)OC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)OCC2=CC=CC=C2

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