Z-His-NH2 is a protected histidine derivative in which the imidazole-containing amino acid side chain is retained while the α-amino group is masked as a benzyloxycarbonyl (Z, Cbz) carbamate. The molecule bears a free carboxamide at the α-position (-NH2) and an imidazole ring on the side chain, providing an additional basic/heteroaromatic functionality that can participate in acid-base interactions during synthesis and analysis. Z-His-NH2 is used as an amino acid building block for preparing histidine-containing peptides and peptide-related intermediates, where the Z protecting group helps control chemoselectivity of coupling and side reactions while the carboxamide functionality supports targeted amide-forming transformations.
CAT No: CP26475
CAS No:16706-41-5
Synonyms/Alias:Z-HIS-NH2;16706-41-5;AC1ODUXF;CARBAMICACID,[2-AMINO-1-(1H-IMIDAZOL-4-YLMETHYL)-2-OXOETHYL]-,PHENYLMETHYLESTER,(S)-(9CI);ZINC1678299;7922AH;AKOS022181218;AJ-29524;AK-60189;K-5175;(S)-Benzyl(1-amino-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)carbamate;benzylN-[(2S)-1-amino-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]carbamate
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