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Z-His-NH2

Z-His-NH2 is a protected histidine derivative in which the imidazole-containing amino acid side chain is retained while the α-amino group is masked as a benzyloxycarbonyl (Z, Cbz) carbamate. The molecule bears a free carboxamide at the α-position (-NH2) and an imidazole ring on the side chain, providing an additional basic/heteroaromatic functionality that can participate in acid-base interactions during synthesis and analysis. Z-His-NH2 is used as an amino acid building block for preparing histidine-containing peptides and peptide-related intermediates, where the Z protecting group helps control chemoselectivity of coupling and side reactions while the carboxamide functionality supports targeted amide-forming transformations.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: CP26475

CAS No:16706-41-5

Synonyms/Alias:Z-HIS-NH2;16706-41-5;AC1ODUXF;CARBAMICACID,[2-AMINO-1-(1H-IMIDAZOL-4-YLMETHYL)-2-OXOETHYL]-,PHENYLMETHYLESTER,(S)-(9CI);ZINC1678299;7922AH;AKOS022181218;AJ-29524;AK-60189;K-5175;(S)-Benzyl(1-amino-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl)carbamate;benzylN-[(2S)-1-amino-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]carbamate

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M.F/Formula
C14H16N4O3
M.W/Mr.
288.31
Size
1 g;5 g;
InChI
1S/C14H16N4O3/c15-13(19)12(6-11-7-16-9-17-11)18-14(20)21-8-10-4-2-1-3-5-10/h1-5,7,9,12H,6,8H2,(H2,15,19)(H,16,17)(H,18,20)/t12-/m0/s1
InChI Key
YLVGCKUYWFCKIV-LBPRGKRZSA-N
Canonical SMILES
C1=CC=C(C=C1)COC(=O)NC(CC2=CN=CN2)C(=O)N

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