Z-His-OBzl contains the imidazole-bearing amino acid histidine in a protected, esterified form, where the α-amino group is carbobenzyloxy-protected (Z/Cbz) and the carboxyl group is converted to a benzyl ester (OBzl). The molecule retains the histidine side-chain imidazole functionality for hydrogen-bonding and acid-base behavior, while the Z protecting group and benzyl ester mask the primary amino and carboxyl functionalities to control chemoselectivity in multi-step synthesis. Z-His-OBzl is used as a protected histidine building block for peptide coupling strategies and for preparing histidine-containing peptide or peptidomimetic intermediates under conditions that require protection of both the amino and carboxyl groups.
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Creative Peptides is a trusted CDMO partner specializing in high-quality peptide synthesis, conjugation, and manufacturing under strict cGMP compliance. With advanced technology platforms and a team of experienced scientists, we deliver tailored peptide solutions to support drug discovery, clinical development, and cosmetic innovation worldwide.
From custom peptide synthesis to complex peptide-drug conjugates, we provide flexible, end-to-end services designed to accelerate timelines and ensure regulatory excellence. Our commitment to quality, reliability, and innovation has made us a preferred partner across the pharmaceutical, biotechnology, and personal care industries.
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