Z-IETD-FMK

Z-IETD-FMK is a selective and cell permeable caspase 8 inhibitor. It also inhibits caspase-10. The bis-methyl ester of Z-IETD-FMK blocked CD95-induced apoptosis.

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CAT No:HB00018

CAS No:210344-98-2

Synonyms/Alias:IETD (Modifications: N-terminal benzyloxycarbonyl; C-terminal FMK; Glu-2 = Glu(OMe); Asp-4 = Asp(OMe))

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M.F/FormulaC30H43FN4O11
M.W/Mr.654.6894
SequenceZ-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F
Labeling TargetCaspase 8
Purity95/98%
ActivityInhibitor
Areas of InterestCancer
Source#Synthetic
Long-term Storage ConditionsSoluble in DMSO
Solubility-20 °C
InChIInChI=1S/C30H43FN4O11/c1-6-17(2)25(35-30(43)46-16-19-10-8-7-9-11-19)28(41)32-20(12-13-23(38)44-4)27(40)34-26(18(3)36)29(42)33-21(22(37)15-31)14-24(39)45-5/h7-11,17-18,20-21,25-26,36H,6,12-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,40)(H,35,43)/t17-,18+,20-,21-,25-,26-/m0/s1
InChI KeyPHLCQASLWHYEMX-DEKIMQJDSA-N
Isomeric SMILESCC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)OC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1
BoilingPoint925.7±65.0 °C at 760 mmHg
Melting PointN/A
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