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Z-IETD-FMK

Z-IETD-FMK is a selective and cell permeable caspase 8 inhibitor. It also inhibits caspase-10. The bis-methyl ester of Z-IETD-FMK blocked CD95-induced apoptosis.

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CAT#	HB00018
CAS	210344-98-2
Synonyms/Alias	IETD (Modifications: N-terminal benzyloxycarbonyl; C-terminal FMK; Glu-2 = Glu(OMe); Asp-4 = Asp(OMe))
M.F/Formula	C30H43FN4O11
M.W/Mr.	654.6894
Sequence	Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH₂F
Labeling Target	Caspase 8
Purity	95/98%
Activity	Inhibitor
Areas of Interest	Cancer

CAT#	Product Name	Inquiry
R1476	Laminin 925-933	Inquiry
R1159	Activated Protein C (390-404), human	Inquiry
R1121	[Gln8]-C517 (LH-RH), chicken	Inquiry
R1857	Autocamtide-2-RelatedInhibitoryPeptide	Inquiry
R0883	APETx2	Inquiry

CAT#	Product Name	M.W	Molecular Formula	Inquiry
10-101-20	Goserelin Acetate	1269.43	C59H84N18O14	Inquiry
10-101-59	Liraglutide	3751.2	C172H265N43O51	Inquiry
R1574	Octreotide	1019.24	C₄₉H₆₆N₁₀O₁₀S₂	Inquiry
10-101-139	Myrcludex B			Inquiry
10-101-285	Teduglutide	3752.08	C164H252N44O55S	Inquiry
R1847	Sermaglutide	4114	C187H291N45O59	Inquiry
R1961	Carbetocin	988.2	C45H69N11O12S	Inquiry

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Source#	Synthetic
Storage	-20°C
Solubility	Soluble in DMSO
Long-term Storage Conditions	-20 °C
InChI	InChI=1S/C30H43FN4O11/c1-6-17(2)25(35-30(43)46-16-19-10-8-7-9-11-19)28(41)32-20(12-13-23(38)44-4)27(40)34-26(18(3)36)29(42)33-21(22(37)15-31)14-24(39)45-5/h7-11,17-18,20-21,25-26,36H,6,12-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,40)(H,35,43)/t17-,18+,20-,21-,25-,26-/m0/s1
InChI Key	PHLCQASLWHYEMX-DEKIMQJDSA-N
Isomeric SMILES	CC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)OC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1
BoilingPoint	925.7±65.0 °C at 760 mmHg
Melting Point	N/A