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Z-Leu-Leu-Glu-AMC

An excellent fluorogenic substrate for measuring the peptidylglutamyl-peptide-hydrolyzing (PGPH) activity of the 20S proteasome, which is excited at 340-360 nm and emits at 440-460 nm. It is typically used in cell lysates after experimental treatment.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
Z-Leu-Leu-Glu-AMC(CAS 348086-66-8)

CAT No: R1025

CAS No:348086-66-8

Synonyms/Alias:Z-Leu-Leu-Glu-AMC;348086-66-8;Z-LLE-AMC;Cbz-Leu-Leu-Glu-AMC;(5S,8S,11S)-5,8-Diisobutyl-11-((4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl)-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatetradecan-14-oic acid;(4S)-4-[[(2S)-4-methyl-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]pentanoyl]amino]-5-[(4-methyl-2-oxochromen-7-yl)amino]-5-oxopentanoic acid;Z-Leu-Leu-Glu-MCA;Z-Leu-Leu-Glu-7-Amino-4-Methylcoumarin;Z-Leu-Leu-Glu-AMC [Z-LLE-AMC];MFCD01074989;Z-LEU-LEU-GLU-7-AMIDO-4-METHYLCOUMARIN;Z-L-Leu-L-Leu-L-Glu-AMC;SCHEMBL15569405;CHEBI:229563;AKOS027327743;Proteasome Substrate II (Fluorogenic);NCGC00485335-01;FL110601;HY-123053;CS-0081090;Z-Leu-Leu-Glu-7-amido-4-methylcoumarin, >=95%, solid;(4S)-4-[(2S)-2-[(2S)-2-{[(BENZYLOXY)CARBONYL]AMINO}-4-METHYLPENTANAMIDO]-4-METHYLPENTANAMIDO]-4-[(4-METHYL-2-OXOCHROMEN-7-YL)CARBAMOYL]BUTANOIC ACID;(5S,8S,11S)-5,8-Diisobutyl-11-((4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl)-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatetradecan-14-oicacid;N-[(benzyloxy)carbonyl]-L-leucyl-L-leucyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-alpha-glutamine;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C35H44N4O9
M.W/Mr.
664.7
Sequence
One Letter Code:LLE
Three Letter Code:Cbz-Leu-Leu-Glu-AMC
Appearance
Solid lyophilized powder
Purity
>95%
Source#
Synthetic
Long-term Storage Conditions
Soluble in DMSO
InChI
InChI=1S/C35H44N4O9/c1-20(2)15-27(38-34(45)28(16-21(3)4)39-35(46)47-19-23-9-7-6-8-10-23)33(44)37-26(13-14-30(40)41)32(43)36-24-11-12-25-22(5)17-31(42)48-29(25)18-24/h6-12,17-18,20-21,26-28H,13-16,19H2,1-5H3,(H,36,43)(H,37,44)(H,38,45)(H,39,46)(H,40,41)/t26-,27-,28-/m0/s1
InChI Key
FOYHOBVZPWIGJM-KCHLEUMXSA-N
Isomeric SMILES
CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC3=CC=CC=C3
BoilingPoint
967.8±65.0 °C at 760 mmHg
Melting Point
N/A

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