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Irreversible, cell permeable caspase-1 (ICE) inhibitor. Inhibits also caspase-4.
CAT No: HB00045
Synonyms/Alias: Caspase-1 Inhibitor, Z-YVAD fluoromethylketone
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M.F/Formula | C31H39FN4O9 |
M.W/Mr. | 630.6704 |
Sequence | Z-YVAD-FMK |
Labeling Target | Caspase-1 |
Application | Cell permeable fluoromethyl ketone (FMK)-derivatized peptides act as effective irreversible Caspase inhibitors with no cytotoxic effects and, therefore, are useful tools for studying Caspase activity. |
Purity | 95/98% |
Activity | Inhibitor |
Source# | Synthetic |
Long-term Storage Conditions | Soluble in DMSO |
Solubility | -20 °C |
InChI | InChI=1S/C31H39FN4O9/c1-18(2)27(30(42)33-19(3)28(40)34-23(25(38)16-32)15-26(39)44-4)36-29(41)24(14-20-10-12-22(37)13-11-20)35-31(43)45-17-21-8-6-5-7-9-21/h5-13,18-19,23-24,27,37H,14-17H2,1-4H3,(H,33,42)(H,34,40)(H,35,43)(H,36,41)/t19-,23-,24?,27-/m0/s1 |
InChI Key | MVPQJUFFTWWKBT-UYDLRUHXSA-N |
Isomeric SMILES | C[C@@H](C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)C(CC1=CC=C(C=C1)O)NC(=O)OCC2=CC=CC=C2 |
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