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10Panx

10Panx is a mimetic inhibitory peptide of panx1, which blocks pannexin-1 gap junctions, inhibits p2x7-mediated dye uptake, atp-mediated il-1β release and caspase-1 activation, but does not alter membrane current in macrophages in vitro.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.
10Panx(CAS 955091-53-9)

CAT No: R0961

CAS No:955091-53-9

Synonyms/Alias:10PANX;955091-53-9;10 Panx;10Panx1;H-Trp-Arg-Gln-Ala-Ala-Phe-Val-Asp-Ser-Tyr-OH;CHEMBL5439198;Panx-1 mimetic inhibitory peptide;HY-P1137;AKOS024457570;DA-49060;PD079477;CS-0028050;

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C58H79N15O16
M.W/Mr.
1242.3
Sequence
One Letter Code:WRQAAFVDSY
Three Letter Code:H-Trp-Arg-Gln-Ala-Ala-Phe-Val-Asp-Ser-Tyr-OH
Labeling Target
Gap Channels
Purity
>98%
Activity
Inhibitor
InChI
InChI=1S/C58H79N15O16/c1-29(2)47(56(87)70-42(26-46(77)78)53(84)72-44(28-74)55(86)71-43(57(88)89)24-33-16-18-35(75)19-17-33)73-54(85)41(23-32-11-6-5-7-12-32)69-49(80)31(4)65-48(79)30(3)66-51(82)40(20-21-45(60)76)68-52(83)39(15-10-22-63-58(61)62)67-50(81)37(59)25-34-27-64-38-14-9-8-13-36(34)38/h5-9,11-14,16-19,27,29-31,37,39-44,47,64,74-75H,10,15,20-26,28,59H2,1-4H3,(H2,60,76)(H,65,79)(H,66,82)(H,67,81)(H,68,83)(H,69,80)(H,70,87)(H,71,86)(H,72,84)(H,73,85)(H,77,78)(H,88,89)(H4,61,62,63)/t30-,31-,37-,39-,40-,41-,42-,43-,44-,47-/m0/s1
InChI Key
JCJASTVQGSKHKZ-QZHJRRRASA-N
Isomeric SMILES
C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)N
BoilingPoint
N/A
Melting Point
N/A

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