ABT-510 is a peptide mimetic of thrombospondin-1 (TSP-1), blocks angiogenesis in vitro and in vivo, and slows tumor growth.
CAT No: R2001
CAS No:251579-55-2
Synonyms/Alias:ABT-510;251579-55-2;ABT 510;UNII-CRR8E37XOB;CRR8E37XOB;Nac-sar-gly-val-(d-allo-ile)-thr-nva-ile-arg-pronet;(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2R,3S)-2-[[(2S)-2-[[2-[[2-[acetyl(methyl)amino]acetyl]amino]acetyl]amino]-3-methylbutanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]pentanoyl]amino]-3-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-ethylpyrrolidine-2-carboxamide;ABT 510 [WHO-DD];ABT-526;L-Prolinamide, N-acetyl-N-methylglycylglycyl-L-valyl-D-alloisoleucyl-L-threonyl-L-norvalyl-L-isoleucyl-L-arginyl-N-ethyl-;(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2R,3S)-2-[[(2S)-2-[[2-[[2-[Acetyl(methyl)amino]acetyl]amino]acetyl]amino]-3-methylbutanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]pentanoyl]amino]-3-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-ethylpyrrolidine-2-carboxamide;(2S)-1-((2S)-2-(((2S,3S)-2-(((2S)-2-(((2S,3R)-2-(((2R,3S)-2-(((2S)-2-((2-((2-(acetyl(methyl)amino)acetyl)amino)acetyl)amino)-3-methylbutanoyl)amino)-3-methylpentanoyl)amino)-3-hydroxybutanoyl)amino)pentanoyl)amino)-3-methylpentanoyl)amino)-5-(diaminomethylideneamino)pentanoyl)-N-ethylpyrrolidine-2-carboxamide;TSP-1 Mimetic ABT-510;CHEMBL386115;DTXSID80870283;TSP-1-mimetic Peptide ABT-510;DB05434;DA-60690;HY-13545;N-acetyl-sarcosyl-glycyl-valyl-alloisoleucyl-threonyl-norvalyl-isoleucyl-arginyl-proline ethylamide;CS-0007141;NS00073490;Q27095674;(S)-N-Ethyl-1-(((S)-2-((2S,3R)-3-hydroxy-2-((2R,3S)-3-methyl-2-((S)-3-methyl-2-(2-(2-(N-methylacetamido)acetamido)acetamido)butanamido)pentanamido)butanamido)pentanoyl)-L-isoleucyl-L-arginyl)pyrrolidine-2-carboxamide;
Chemical Name:(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2R,3S)-2-[[(2S)-2-[[2-[[2-[acetyl(methyl)amino]acetyl]amino]acetyl]amino]-3-methylbutanoyl]amino]-3-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]pentanoyl]amino]-3-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-ethylpyrrolidine-2-carboxamide
ABT-510 is a synthetic peptide analog derived from the active domain of thrombospondin-1, a matricellular glycoprotein known for its multifaceted regulatory roles in cell-matrix interactions and angiogenesis. As a stable and bioactive peptide, ABT-510 has garnered significant attention in the field of biochemical and cell biology research, particularly for its capacity to modulate angiogenic processes and its well-characterized mechanism of action involving the inhibition of endothelial cell proliferation. Its defined sequence and high specificity make it an invaluable tool for dissecting cellular pathways related to vascular biology, tumor microenvironment studies, and extracellular matrix signaling.
Angiogenesis research: ABT-510 is extensively employed as a reference compound in studies investigating the molecular mechanisms of angiogenesis. By mimicking the anti-angiogenic activity of thrombospondin-1, it enables researchers to delineate the signaling pathways that regulate new blood vessel formation. Its application is particularly valuable in in vitro assays using endothelial cell cultures, where it serves to evaluate the inhibitory effects on vascular tube formation and cell migration. This facilitates a deeper understanding of the balance between pro- and anti-angiogenic factors within physiological and pathological contexts.
Tumor microenvironment modeling: The peptide is widely utilized in experimental models that aim to replicate the complex cellular interactions within the tumor microenvironment. By modulating the activity of endothelial cells and influencing the secretion of matrix proteins, ABT-510 helps elucidate the role of extracellular matrix-derived signals in tumor progression and metastasis. Its use in three-dimensional co-culture systems and organotypic models supports advanced investigations into stromal-epithelial crosstalk and the mechanisms by which tumors regulate their vascular supply.
Cell signaling pathway analysis: ABT-510 serves as a precise molecular probe for dissecting intracellular signaling cascades downstream of thrombospondin receptors, such as CD36. Through targeted inhibition of specific pathways, it allows researchers to map the involvement of key kinases, transcription factors, and regulatory proteins implicated in cell survival, apoptosis, and migration. Employing this peptide in biochemical assays, such as Western blotting or reporter gene analyses, provides valuable insights into the modulation of cellular responses by extracellular peptides.
Peptide-based inhibitor screening: As a well-characterized anti-angiogenic peptide, ABT-510 is frequently used as a positive control or benchmark in high-throughput screening platforms designed to identify novel peptide-based inhibitors of angiogenesis. Its inclusion in assay development ensures robust validation of screening methodologies and facilitates the comparative evaluation of new candidate molecules. This application is particularly relevant for research groups developing next-generation peptide therapeutics or investigating structure-activity relationships among thrombospondin-derived analogs.
Extracellular matrix interaction studies: The ability of ABT-510 to interact with components of the extracellular matrix and modulate cell adhesion makes it a valuable reagent in studies focused on cell-matrix dynamics. Researchers utilize the peptide to probe the influence of matrix-derived signals on cell morphology, migration, and differentiation. Its defined mechanism of action provides a controlled means to manipulate cellular responses in both two-dimensional and three-dimensional culture systems, thereby advancing the understanding of tissue remodeling and repair processes in developmental biology and disease models.
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