Acetyl-(D-Phe2,Lys15,Arg16,Leu27)-VIP (1-7)-GRF (8-27) is a chimeric peptide blending VIP and GRF motifs with strategically placed substitutions. These modifications adjust charge, aromatic character, and helix stability. The acetylation further supports structural uniformity in biochemical assays. Researchers use the construct to explore signaling mechanisms shared across VIP and GRF pathways.
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