Acetyl Tetrapeptide-2

Acetyl Tetrapeptide-2 is a synthetic peptide composed of four amino acids designed for use in cosmetic formulations targeting skin care applications. Recognized for its biomimetic properties, it supports the maintenance of skin's structural integrity and resilience. Suitable for a range of leave-on products, Acetyl Tetrapeptide-2 is compatible with various formulation types and aligns with global cosmetic regulatory standards for safe use in topical applications.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: CPC1665

CAS No:757942-88-4

Synonyms/Alias:757942-88-4; Acetyl tetrapeptide-2; N2-Acetyl-L-lysyl-L-alpha-aspartyl-L-valyl-L-tyrosine; Ac-lys-asp-val-tyr; Peptigravity; Thymulen 4; M24S4WZS8J; UNII-M24S4WZS8J; Acetyl tetrapeptide-2 [INCI]; (3S)-3-[[(2S)-2-acetamido-6-aminohexanoyl]amino]-4-[[(2S)-1-[[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid; L-Tyrosine, N2-acetyl-L-lysyl-L-alpha-aspartyl-L-valyl-; L-TYROSINE, N2-ACETYL-L-LYSYL-L-.ALPHA.-ASPARTYL-L-VALYL-; SCHEMBL24739787; C26H39N5O9; (2S,5S,8S,11S)-11-(4-Aminobutyl)-8-(carboxymethyl)-2-(4-hydroxybenzyl)-5-isopropyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazatetradecan-1-oic acid; (3S)-3-[(2S)-6-amino-2-acetamidohexanamido]-3-{[(1S)-1-{[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]carbamoyl}-2-methylpropyl]carbamoyl}propanoic acid; HY-P2663; MFCD30573923; AKOS030573454; DA-75919; DS-19818; CS-0138091; C76421; Q27283376; N2-Acetyl-L-lysyl-L-alpha-aspartyl-L-valyl-L-tyrosine (Ac-Lys-Asp-Val-Tyr-OH); (2S,5S,8S,11S)-11-(4-aminobutyl)-8-(carboxymethyl)-2-(4-hydroxybenzyl)-5-isopropyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazatetradecanoic acid

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cGMP Peptide
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  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C26H39N5O9
M.W/Mr.
565.62
Sequence
One Letter Code:KDVY
Three Letter Code:Ac-Lys-Asp-Val-Tyr-OH
Functions
Acetyl tetrapeptide-2 is most commonly used as a skin conditioner, by soothing and nourishing the skin through similar mechanisms as other peptides. It is done by compensating for hormone loss in the skin, especially collagen, providing somewhat of a plumping effect to the skin.

Mechanism of Action (MOA)

Acetyl Tetrapeptide-2 is a biomimetic signaling peptide designed to support cellular communication pathways associated with skin structure. It interacts with key receptors involved in the synthesis and organization of extracellular matrix components, such as collagen and elastin. By modulating cellular signaling cascades, Acetyl Tetrapeptide-2 helps maintain the functional integrity of the skin's architecture, contributing to the appearance of improved skin resilience and firmness.

Acetyl Tetrapeptide-2 is suitable for incorporation into a variety of cosmetic formulations targeting skin care.

- Recommended for use in facial creams, lotions, and serums
- Can be included in formulations for body care products
- Compatible with emulsions and gel-based systems
- Suitable for daily-use skincare routines
- Suggested inclusion levels typically range from 1% to 5%
- Stable in both oil-in-water and water-in-oil formulations

INCIName
ACETYL TETRAPEPTIDE-2
InChI
InChI=1S/C26H39N5O9/c1-14(2)22(25(38)30-20(26(39)40)12-16-7-9-17(33)10-8-16)31-24(37)19(13-21(34)35)29-23(36)18(28-15(3)32)6-4-5-11-27/h7-10,14,18-20,22,33H,4-6,11-13,27H2,1-3H3,(H,28,32)(H,29,36)(H,30,38)(H,31,37)(H,34,35)(H,39,40)/t18-,19-,20-,22-/m0/s1
InChI Key
ITIMHIATVYROGF-XWUOBKMESA-N

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