(1-Adamantanecarbonyl-D-Arg0,Hyp3,beta-(2-thienyl)-Ala5·8,D-Phe7)-Bradykinin is a highly modified bradykinin analog integrating hydrophobic, aromatic, and cyclic substituents for extreme conformational refinement. These changes dramatically influence steric bulk, hydrogen-bond frameworks, and receptor engagement. The analog is ideal for probing kinin structural requirements and signaling bias. Researchers use it in deep analyses of peptide topology and binding-site mapping.
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