Potent and selective KV1.3 channel blocker (IC50 values are 0.0019 and 0.65 nM for KV1.3 and KV1.1, respectively). Inhibits CD4+ CCR7- T cell activation. It is a useful tool for studying the structure-function of Kv1.3 channel and auto-immunity pathways.
CAT No: R1063
ADWX 1 is a synthetic peptide compound engineered for advanced research applications in the fields of biochemistry, molecular biology, and peptide-based functional studies. As a custom-designed peptide, it features a unique amino acid sequence that enables selective interactions with specific biological targets, making it a valuable tool for probing protein-protein interactions, receptor binding, and intracellular signaling pathways. Its chemical stability and tailored structure provide researchers with a versatile platform for investigating complex biochemical phenomena and elucidating the mechanisms underlying peptide-mediated cellular processes.
Peptide-protein interaction studies: ADWX 1 is widely utilized in the analysis of peptide-protein interactions, serving as a probe to map binding sites, characterize affinity, and dissect interaction specificity within complex biological systems. By incorporating this peptide into binding assays or pull-down experiments, researchers can systematically explore the molecular determinants of protein recognition and modulation, thereby gaining insights into the structural and functional aspects of target proteins.
Signal transduction research: The compound's defined sequence allows it to function as a modulator or mimic of endogenous signaling peptides, facilitating the study of intracellular pathways regulated by peptide ligands. In cellular assays, it can be employed to activate, inhibit, or compete with natural ligands, enabling precise dissection of signaling cascades and downstream biological effects. This application is particularly relevant in efforts to unravel the roles of specific peptide motifs in cellular communication and regulatory networks.
Peptide synthesis validation: ADWX 1 is frequently used as a reference standard or model peptide in peptide synthesis laboratories. Its well-characterized sequence and predictable behavior in chromatographic and spectrometric analyses make it an ideal candidate for validating synthetic protocols, optimizing purification strategies, and benchmarking analytical instrumentation. By comparing experimental results with those obtained from this synthetic peptide, researchers can ensure the reliability and reproducibility of their peptide production workflows.
Structure-activity relationship (SAR) studies: The compound is instrumental in SAR investigations aimed at correlating peptide sequence variations with biological activity. By systematically modifying residues within the ADWX 1 scaffold, scientists can assess the impact of specific amino acid substitutions on binding affinity, stability, and functional potency. These studies are essential for rational peptide design, enabling the development of optimized analogs for both basic research and translational applications.
Biochemical assay development: ADWX 1 is also employed in the creation and optimization of biochemical assays that require defined peptide substrates or ligands. Its stability and sequence specificity make it suitable for use in enzyme kinetics experiments, receptor binding assays, and high-throughput screening platforms. By integrating this peptide into assay systems, researchers can achieve greater sensitivity, selectivity, and reproducibility, thereby advancing the development of robust and informative experimental protocols.
3. Cell-based adhesion assays for isolation of snake venom’s integrin antagonists
4. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
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