Alexamorelin features a designed peptide structure used to investigate receptor-mediated growth-related pathways in biochemical systems. Its residue arrangement promotes defined secondary structure formation. The compound's physicochemical profile facilitates binding and stability assessments. Studies employ it in ligand optimization, signaling pathway mapping, and engineered peptide research.
CAT No: R2299
CAS No:196808-85-2
Synonyms/Alias:Alexamorelin;196808-85-2;L-Alanyl-L-histidyl-2-methyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide;Ala-His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2;(2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(2-methyl-1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide;SCHEMBL21118232;HY-P0166;CS-6140;DA-70688;
Alexamorelin is a synthetic peptide compound classified as a growth hormone secretagogue, structurally designed to mimic the action of endogenous ghrelin. As a pentapeptide, it selectively binds to the growth hormone secretagogue receptor (GHS-R1a), thereby stimulating the release of growth hormone in various biological systems. Its unique sequence and receptor affinity make it a valuable reagent for probing hormonal regulation, signal transduction, and peptide-receptor interactions in experimental settings. Due to its well-characterized mechanism and reliable pharmacological profile, Alexamorelin is widely utilized in peptide research, endocrine studies, and biochemical assay development.
Peptide-receptor interaction studies: Alexamorelin serves as a precise tool for investigating the molecular mechanisms underlying GHS-R1a activation and downstream signaling pathways. By providing a consistent and selective agonist, researchers can dissect the conformational dynamics and ligand-binding properties of the growth hormone secretagogue receptor. Such studies are instrumental in mapping receptor structure-function relationships and in validating novel GHS-R1a modulators through competitive binding or functional assays.
Endocrine pathway research: The compound is extensively used to model and analyze the physiological regulation of growth hormone secretion in vitro and in vivo. By applying it to cultured pituitary cells or animal models, investigators can monitor hormone release profiles, gene expression changes, and feedback mechanisms within the somatotropic axis. These applications are critical for understanding the broader context of metabolic regulation, energy homeostasis, and endocrine feedback loops.
Peptide synthesis and analog development: As a well-characterized pentapeptide, Alexamorelin provides a reference framework for the design and synthesis of novel peptide analogs with modified receptor affinities or altered pharmacokinetic properties. Synthetic chemists and peptide engineers utilize its sequence to explore structure-activity relationships, optimize peptide stability, and develop new molecules for research into GHS-R1a-targeted pathways. This approach supports the rational development of next-generation secretagogues and related peptide tools.
Cell signaling investigations: The compound is a valuable reagent for elucidating the intracellular cascades triggered by growth hormone secretagogue receptor activation. By applying it to various cell lines, researchers can study G-protein coupled receptor (GPCR) signaling events, including calcium mobilization, cAMP production, and kinase activation. These experiments provide insight into the broader signaling networks modulated by GHS-R1a and facilitate the identification of downstream effectors and regulatory nodes.
Assay development and validation: Laboratories engaged in the development of bioassays or high-throughput screening platforms use Alexamorelin as a positive control or standard agonist for GHS-R1a activity. Its predictable and reproducible effects enable the calibration of assay sensitivity, specificity, and dynamic range. By incorporating this peptide into assay workflows, researchers ensure robust evaluation of novel secretagogues, antagonists, or signaling modulators targeting the growth hormone secretagogue pathway.
2. SERS spectrum of the peptide thymosin‐β4 obtained with Ag nanorod substrate
3. TMEM16F and dynamins control expansive plasma membrane reservoirs
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