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Amylin (14-20) (human)

The formation of amyloid deposits by IAPP could play a central role in the pathogenesis of type II diabetes. Besides the amyloidogenic 20-29 region, the domain NFLVHSS (IAPP 14-20) tends to aggregate and seems to be involved in plaque formation. The peptide NFLVHSS (IAPP 14-20) tends to aggregate and seems to be involved in plaque formation.

Designed for biological research and industrial applications, not intended for individual clinical or medical purposes.

CAT No: A12019

CAS No:121341-77-3

Synonyms/Alias:L-asparagyl-L-phenylalanyl-L-leucyl-L-valyl-L-histidyl-L-seryl-L-serine

Chemical Name:(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoic acid

Custom Peptide Synthesis
cGMP Peptide
  • Registration of APIs
  • CMC information required for an IND
  • IND and NDA support
  • Drug master files (DMF) filing
M.F/Formula
C36H54N10O11
M.W/Mr.
802.89
Sequence
One Letter Code: NFLVHSS
Three-Letter Code: H-Asn-Phe-Leu-Val-His-Ser-Ser-OH
Source#
Synthetic
Long-term Storage Conditions
Soluble in DMSO
InChI
InChI=1S/C36H54N10O11/c1-18(2)10-23(42-31(51)24(11-20-8-6-5-7-9-20)41-30(50)22(37)13-28(38)49)33(53)46-29(19(3)4)35(55)43-25(12-21-14-39-17-40-21)32(52)44-26(15-47)34(54)45-27(16-48)36(56)57/h5-9,14,17-19,22-27,29,47-48H,10-13,15-16,37H2,1-4H3,(H2,38,49)(H,39,40)(H,41,50)(H,42,51)(H,43,55)(H,44,52)(H,45,54)(H,46,53)(H,56,57)/t22-,23-,24-,25-,26-,27-,29-/m0/s1
InChI Key
NYWRQILLKJSDDP-UIRCOLITSA-N
Canonical SMILES
CC(C)CC(C(=O)NC(C(C)C)C(=O)NC(CC1=CN=CN1)C(=O)NC(CO)C(=O)NC(CO)C(=O)O)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)N)N
Isomeric SMILES
CC(C)C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(=O)N)N

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