The formation of amyloid deposits by IAPP could play a central role in the pathogenesis of type II diabetes. Besides the amyloidogenic 20-29 region, the domain NFLVHSS (IAPP 14-20) tends to aggregate and seems to be involved in plaque formation. The peptide NFLVHSS (IAPP 14-20) tends to aggregate and seems to be involved in plaque formation.
CAT# | A12019 |
CAS | 121341-77-3 |
Synonyms/Alias | L-asparagyl-L-phenylalanyl-L-leucyl-L-valyl-L-histidyl-L-seryl-L-serine |
Chemical Name | (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoic acid |
M.F/Formula | C36H54N10O11 |
M.W/Mr. | 802.89 |
Sequence | One Letter Code: NFLVHSS Three-Letter Code: H-Asn-Phe-Leu-Val-His-Ser-Ser-OH |
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